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Psychiatric Medications (Main Menu)

Psychiatric Medications


Below are links to the MANY articles on this website about Psychiatric Medications, which is the title of the relevant chapter in the DSM-5-TR®.

Also see:

– Side Effects (Main Menu)
– Drug Interactions (Main Menu)


Since we have a large number of articles, we have organized them into several Menus that list and link to all the articles on this website, so that our Members (subscribers) can quickly find the information they are looking for.

How to use the Menus

1. At the top of every page on the website, you will find a tab for *MENUS*. Click on that tab to get to a list of all the main menus.

2. Click on the broad categories below to expand them and see links to all our articles under that category. When you are done, click the category again to collapse it.

For our Members (subscribers) only: If you have any difficulty finding the article you need, just email us, and we’ll locate it for you.



Prescribing-related articles

How to get advice if extra medication is taken by mistake

Your patient may be taking a psychiatric medication by another brand name

How to find basic information about medications on this website

Tips for writing prescriptions: for how long, how many refills?

Is e-prescribing worth it?

Prescription Drug Monitoring Programs (PDMPs)

Where to look up information on drug shortages

Should we send only a “trial prescription”?


Psychopharmacology in Special Populations

Agitation

Dexmedetomidine (Igalmi™): Basic information


Bariatric surgery

What to do about medications after bariatric surgery

How to manage lithium treatment before and after bariatric surgery

Is bupropion sustained-release OK to use after bariatric surgery?

Why and how to monitor and evaluate for suicide risk after bariatric surgery

Why, who, and how to monitor for increased alcohol use after bariatric surgery


Pregnancy and lactation

Always keep in mind the possibility of a future pregnancy

Five websites for information regarding psychotropic medications and pregnancy

Lactation and psychotropic medications: Resources

Pregnancy registries for women who become pregnant while on a psychotropic medication

Is lamotrigine use during pregnancy safe?

Tips on using lithium during pregnancy

Are the Z-drugs (zolpidem and others) safe to take during pregnancy?

Are you about to prescribe a medication that could lead to an unwanted pregnancy?

Cannabis Use During Pregnancy and Lactation: Key Facts and Recommendations


Surgery and anesthesia

What to do about psychotropic medications during elective major surgery

Can patients who are NPO not take medications orally?

Demystified: Potentially very serious interactions between MAO inhibitors (MAOI) and opioid analgesics

What to do about stimulant medications for surgery or other procedures under anesthesia


Other

What happened with my patient when she couldn’t swallow pills

Sometimes, a medication may be given rectally

Are psychiatric medications safe AFTER laser iridotomy for narrow-angle glaucoma?

What to do about psychiatric medications during the month of Ramadan


Medication Interactions with Food

Which psychiatric medications MUST be taken with food?

For medications that must be taken “with food,” how recent does the eating have to be?

Which psychotropic medications should be taken WITHOUT food?

Medications to be taken consistently, either with or without food

Do’s and don’ts regarding mixing medication with food or beverages


Resources for Patients

What is the ONE website that is BEST for all your patient education needs?

FDA-approved “Medication Guides” for patients

Patient handouts: Potential side effects of psychiatric medications

Patient handouts from Simple and Practical

The BEST app for medication reminders/medication management

What are the BEST books on each topic related to psychiatry/ mental health?


  Anti-Addiction Medications


  Antianxiety Medications


  Antidepressant Medications


  Antipsychotic Medications


Agitation medications

Dexmedetomidine (Igalmi™): Basic information

Should we use droperidol, which is available again?


Antiamyloid antibodies

Antiamyloid antibodies—General articles

New, “disease-modifying” treatments for Alzheimer’s disease

Why amyloid-β and amyloid plaques are so important


Antiamyloid antibodies—Lecanemab

Untangling exactly whom lecanemab (Leqembi®) is FDA-approved for

How well does lecanemab (Leqembi®) work?

Should we recommend treatment with lecanemab (Leqembi®)?

Lecanemab (Leqembi®) carries an important boxed warning


Antiamyloid antibodies—Donanemab

A brief review of donanemab (Kisunla®) for Alzheimer’s disease


Anticholinergic medications

Should we routinely prescribe an anticholinergic with an antipsychotic?

Anticholinergic medications prescribed by mental health clinicians: Menu of options

Clinically important differences between anticholinergic medications

For how long should anticholinergics be given for antipsychotic-induced parkinsonism?

After a few months, try to reduce/ stop anticholinergic medication

How does toxicity from anticholinergic medications present clinically?

Cholinergic rebound syndrome: Why we should NOT stop anticholinergic medications abruptly

An anticholinergic medication for antidepressant discontinuation (withdrawal)?

Topical anticholinergics for localized hyperhidrosis


Beta-blockers

Clinical tips on using a beta-blocker for performance anxiety (“stage fright”)

Beta-blockers for panic disorder?

Akathisia: Treatment with a beta-blocker

Beta-blockers for lithium-induced benign tremor

What are the different types of beta-blockers?

Can beta-blockers cause depression or is this a myth?

CNS side effects of beta-blockers

Beta-blockers can either worsen or improve erectile dysfunction

Which beta-blockers in persons with diabetes?

Are beta-blockers contraindicated in asthma?


Bibliotherapy

Bibliotherapy: Recommend books to your patients and their families

BEST Books on Depressive disorders: for patients and families

BEST books on how to change habits

BEST books about how to lose weight

An Unquiet Mind

BEST books on Alzheimer’s disease and other dementias

BEST books on Adult Asperger’s Syndrome

Best books on adult ADHD: For patients and families

Book review: Mindfulness prescription for Adult ADHD

Book review: ADHD-Friendly Ways to Organize Your Life

Best book for choosing a rehab


  Cholinesterase Inhibitors—see Cognitive Enhancers


Cognitive Enhancers

Cholinesterase Inhibitors

Alzheimer’s disease: Medications

How to choose a cholinesterase inhibitor

Switch cholinesterase inhibitors?

Medications for dementia: Alternative preparations

What is benzgalantamine (Zunveyl®) and how is it different?

Donepezil (Aricept®, Aricept ODT®): Basic Information

Galantamine (Razadyne, Razadyne ER): Basic Information

Rivastigmine (Exelon®, Exelon® Patch): Basic Information

In what situations should we STOP cholinesterase inhibitors in patients with dementia?


Memantine

Memantine (Namenda®, Namenda XR®): Basic Information


Digital therapeutics

What is NightWare and should we recommend it to persons with nightmares?


Dopamine Agonists

Dopamine agonists—General articles

Can a dopamine agonist (pramipexole, ropinirole) and a stimulant be combined?

Dopamine agonist withdrawal syndrome (DAWS)


Pramipexole

Pramipexole: Basic information

Pramipexole for major depressive disorder or bipolar depression

Tips on using pramipexole for mood disorders

Potential adverse effects of pramipexole

Can a dopamine agonist (pramipexole, ropinirole) and a stimulant be combined?

Important! Dopamine agonist withdrawal syndrome (DAWS)


Ropinirole

Can a dopamine agonist (pramipexole, ropinirole) and a stimulant be combined?

Ropinirole (Requip®, Requip XL®) for major (unipolar) depression or bipolar depression?

Important! Dopamine agonist withdrawal syndrome (DAWS)


GABA-A positive modulators

Zuranolone (Zurzuvae®): Key facts

 


  Hypnotic Medications


Ketogenic diet and psychotropic medications

Ketogenic diet and amphetamines

Ketogenic diet and topiramate

Ketogenic diet and valproate


Medications for treating feeding and eating disorders

Lisdexamfetamine (Vyvanse®) for binge-eating disorder


Medications for treating obsessive-compulsive and related disorders

SSRIs for OCD

Higher than usual doses of SSRIs for OCD?

SSRIs for OCD: How high can we go?

Clomipramine versus SSRIs for OCD

Add clomipramine to an SSRI for OCD?

Concerns about combining clomipramine and SSRIs

How exactly to add clomipramine to an SSRI

When and how to check the clomipramine level

How to interpret clomipramine and desmethylclomipramine levels

OCD: Second-line medications

Antipsychotic “augmentation” for OCD

Is fluvoxamine more effective for OCD than other SSRIs?

N-acetylcysteine (NAC) for obsessive-compulsive disorder (OCD)?

Poor man’s vortioxetine

Body Dysmorphic Disorder: Pharmacological treatment

How to use serotonin reuptake inhibitors to treat body dysmorphic disorder

How to treat excoriation (skin picking) disorder: Pharmacological treatment


Medications for treating sexual dysfunction

General

Beta-blockers can worsen or improve erectile dysfunction

Cyproheptadine (Periactin®) for antidepressant-induced sexual dysfunction (ADISD)?

Which antidepressant for the treatment of premature ejaculation?

Treatment of premature ejaculation with antidepressants—daily or as-needed?


Flibanserin

Flibanserin (Addyi®)

Flibanserin (Addyi®) in postmenopausal women

Flibanserin (Addyi®): Basic information

Flibanserin (Addyi®): Systematic list of references


Phosphodiesterase-5 inhibitors (PDE-5 inhibitors)

Which PDE-5 inhibitor for erectile dysfunction?


Medications for treating trauma and stress-related disorders

Does prazosin work for PTSD? If so, for which symptoms?

How exactly should we dose prazosin in PTSD?

Warning! Prazosin can lead to hypotension/ syncope after the first dose

PTSD-associated nightmares: Menu of treatment options

Are psychostimulant medications contraindicated in persons with PTSD?


Melatonin receptor agonists

Melatonin

Melatonin: An introduction

Does melatonin work for insomnia?

Low-dose preparations of melatonin

Which brand and preparation of melatonin to recommend

Melatonin agonists for preventing and treating delirium?

What are the potential side effects of melatonin?

Does melatonin need to be gradually tapered off when stopping it?

Can melatonin have negative effects on puberty?  

Can melatonin increase blood sugar?

What drug interactions can occur with melatonin?


Ramelteon

Pros and cons of ramelteon (Rozerem) as a hypnotic

Ramelteon (Rozerem®): Basic Information


Miscellaneous

Melatonin agonists for preventing and treating delirium?

Melatonin agonists for sundowning in major neurocognitive disorder (dementia)?


  Mood Stabilizer Medications


Muscarinic agonist

Xanomeline+Trospium (Cobenfy™)

The rationale for xanomeline+trospium (Cobenfy™), approved for the treatment of schizophrenia

Efficacy of xanomeline+trospium (Cobenfy™) and comparison with second-generation antipsychotics

Xanomeline+trospium (Cobenfy™): Side effects


Psychedelics

Considerable beneficial effects are reported by psilocybin users

What side effects can psilocybin have?

Can psilocybin lead to suicide or other self-harm?

Is psilocybin addictive?

Can psychedelics cause serotonin toxicity (syndrome)?

Can a psychedelic be taken along with lithium?

What we need to know about hallucinogen persisting perception disorder (HPPD)


 Stimulant (Psychostimulant) Medications


Thyroid hormones

Thyroid hormones for psychopharmacologists: What’s what 

Pros and cons of liothyronine (T3) and levothyroxine (T4)

Levothyroxine (T4) for augmentation of antidepressants? 

Thyroid hormone for adjunctive treatment (augmentation) with an SSRI?

Liothyronine (T3) adjunctive treatment: How much and for how long?

Which thyroid hormone to use if one is needed for lithium-induced hypothyroidism


Vesicular monoamine transporter 2 (VMAT2) Inhibitors

Deutetrabenazine

Deutetrabenazine (Austedo®): Basic Information


Valbenazine

Valbenazine (Ingrezza®) and VMAT2

Valbenazine (Ingrezza®): Basic information


General

VMAT2 inhibitor? What’s that?

Comparing the VMAT2 inhibitors


  Vitamins and Minerals


Wakefulness-promoting agents

Armodafinil

Do modafinil/ armodafinil need cardiovascular monitoring

Armodafinil (Nuvigil®): Basic Information


Modafinil

Modafinil for ADHD?

Modafinil as an adjunct for major depressive disorder?

Do modafinil/ armodafinil need cardiovascular monitoring

Modafinil (Provigil®): Basic Information


Solriamfetol

Solriamfetol (Sunosi®): Basic Information


  Weight-Loss Medications and Treatments


Cost of Medications

How to find out the price of medications, compare prices, and get the lowest possible price

Tips on reducing the cost of medications by using higher-strength pills

Should we encourage patients to use independent pharmacies?

A simple way to significantly reduce the cost of l-methylfolate (Deplin®)


Prescription drug plans

What is the procedure for obtaining an early medication refill?

Prior authorization for medications

Pharmacy benefit managers


Online pharmacies

Should we recommend Costplusdrugs.com for lowering the cost of medications?

Medication prices on Costco.com versus on Goodrx.com

Can patients who have Medicare Part D use GoodRx coupons or CostPlusDrugs.com?

Medications from Canadian pharmacies?

Using a Canadian pharmacy can reduce the cost of some medications


Formulations of medications

Formulations of medications—General articles

Abbreviations for controlled-release formulations are out of control!

Antidepressants: What are the alternatives to the oral route?


Formulations of medications—Capsules

Do sustained-release preparations have fewer adverse effects?

Extended-release preparations of psychotropic medications

Can extended-release capsules be opened?

When a patient has difficulty getting off venlafaxine

How can duloxetine be tapered very slowly?

Two patients for whom opening medication capsules was helpful


Formulations of medications—Tablets

Are bupropion SR and bupropion ER the same thing?

Why, when, and how to split medication tablets

Recommended pill cutters and pill crushers

Which tablets are actually extended-release formulations and so should not be cut?

What if patients report seeing intact pills in their stools?


Formulations of medications—Orally disintegrating tablets (ODTs)

Orally disintegrating tablets (ODT) can be useful

Tips on using clonazepam orally disintegrating tablets (ODT)


Formulations of medications—Sublingual

Psychotropic medications are sometimes given sublingually


Formulations of medications—Liquids

Which antidepressants come in liquid forms?


Inactive Ingredients (Excipients) in Medications

Gluten in medications

Can lactose in medication pills cause intolerance?

How to find out whether a medication contains ingredients of animal origin


Generic medications

Are generic medications really equivalent to brand-name medications?

Generic and “authorized generic” medications

Which manufacturers of generic versions of psychotropic medications are better or worse?

Which generics of Concerta® (methylphenidate extended-release) to recommend

Is generic bupropion as effective as brand-name Wellbutrin®?

Can generic dextromethorphan and bupropion be used instead of the brand-name combination?

A generic alternative to naltrexone/bupropion (Contrave®)?


Laws and Regulations About Medications

Laws about prescriptions for psychostimulants

Can I take my medication with me when I travel to another country?

What patients taking a stimulant medication must know before visiting Japan


Off-Label Prescribing

We prescribe “off-label” more often than we think

Important! Off-label prescribing is of many different types

Off-label prescribing: Clinical recommendations


Pharmacodynamics and Pharmacokinetics

Which medications are mostly excreted unchanged, and why is this important?

Some medications have a low “therapeutic index”. What exactly is that?

Psychiatric medications with a long half-life

ABCB1 polymorphisms and psychotropic medications

Why is dextromethorphan combined with a CYP 2D6 inhibitor?

What does the Ki (inhibition constant) for a drug mean?

A simple guide to serotonin receptors

Dopamine receptors: A primer for clinicians

Melanocortin 4 receptor (MC4R) and weight gain


Miscellaneous articles

What to do about old prescriptions

Short answers to questions from our Members

Can persons on psychotropic medications donate blood?

What do the es-, the levo-, and the dex- mean in drug names?

Flibanserin (Addyi®)

Milnacipran (Savella®): Basic Information

What happened with my patient when she couldn’t swallow pills

Sometimes, a medication may be given rectally

What to do about psychiatric medications during the month of Ramadan


Also see:

– Side Effects (Main Menu)
– Drug Interactions (Main Menu)


Copyright © 2018 to 2026, Simple and Practical Medical Education, LLC. All rights reserved. The content on this website may not be reproduced in any form without express written permission.

Disclaimer: The material on this website is provided as general education for medical professionals. It is not intended for patients or other laypersons, nor is it a substitute for medical advice, diagnosis, or treatment. Patients must always consult a qualified healthcare professional regarding their diagnosis and treatment. Healthcare professionals should always check this website for the most up-to-date information.

Comments

  1. Shira Rubinstein says

    November 6, 2023 at 9:12 pm

    What articles do you have on treatments for perimenopausal mood and vasomotor symptoms?
    Specifically I am looking for article on SSRIs and SNRIs and other non-hormonal options.
    Many thanks

    • Rajnish Mago, MD says

      November 12, 2023 at 5:27 pm

      I went to our Main Menu for “Disorders/ Conditions” and, in that Menu, to the category of “Women’s mental health”. It showed that we have the following two articles about perimenopausal symptoms and their treatment:

      Tips on managing perimenopausal symptoms

      Adjunctive estrogen for perimenopausal depression?

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