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Other Psychiatric Medications (Main Menu)

Psychiatric Medications

– This Menu contains links to pages related to various OTHER PSYCHIATRIC MEDICATIONS.

– Some general topics related to psychiatric medications are listed first, followed by articles related to specific categories of psychiatric medications

– Also see Side Effects (Main Menu) and Drug Interactions (Main Menu)

– Additional Main Menus can be found by hovering over the MENUS tab at the top of every page on this website.


– In the Menu below, click on the category (or the arrow to the left of its name) to EXPAND the category and see what is included in it. When you are done, click on the category (or the arrow to the left of it) to COLLAPSE the category back.


Prescribing-related articles

How to get advice if extra medication is taken by mistake

Your patient may be taking a psychiatric medication by another brand name

How to find basic information about medications on this website

Tips for writing prescriptions: for how long, how many refills?

Is e-prescribing worth it?

Prescription Drug Monitoring Programs (PDMPs)

Where to look up information on drug shortages


Psychopharmacology in Special Populations

Agitation

Dexmedetomidine (Igalmi™): Basic information


Bariatric surgery

What to do about medications after bariatric surgery

How to manage lithium treatment before and after bariatric surgery

Is bupropion sustained-release OK to use after bariatric surgery?

Why and how to monitor and evaluate for suicide risk after bariatric surgery

Why, who, and how to monitor for increased alcohol use after bariatric surgery


Pregnancy and lactation

Always keep in mind the possibility of a future pregnancy

Five websites for information regarding psychotropic medications and pregnancy

Lactation and psychotropic medications: Resources

Pregnancy registries for women who become pregnant while on a psychotropic medication

Is lamotrigine use during pregnancy safe?

Tips on using lithium during pregnancy

Are the Z-drugs (zolpidem and others) safe to take during pregnancy?

Are you about to prescribe a medication that could lead to an unwanted pregnancy?

Cannabis Use During Pregnancy and Lactation: Key Facts and Recommendations


Surgery and anesthesia

What to do about psychotropic medications during elective major surgery

Can patients who are NPO not take medications orally?

Demystified: Potentially very serious interactions between MAO inhibitors (MAOI) and opioid analgesics

What to do about stimulant medications for surgery or other procedures under anesthesia


Other

Are psychiatric medications safe AFTER laser iridotomy for narrow-angle glaucoma?


Medication Interactions with Food

Which psychiatric medications MUST be taken with food?

For medications that must be taken “with food,” how recent does the eating have to be?

Which psychotropic medications should be taken WITHOUT food?

Medications to be taken consistently, either with or without food

Do’s and don’ts regarding mixing medication with food or beverages


Resources for Patients

What is the ONE website that is BEST for all your patient education needs?

FDA-approved “Medication Guides” for patients

Patient handouts: Potential side effects of psychiatric medications

Patient handouts from Simple and Practical

The BEST app for medication reminders/medication management

What are the BEST books on each topic related to psychiatry/ mental health?


  Antianxiety Medications


  Antidepressant Medications


  Antipsychotic Medications


Agitation medications

Dexmedetomidine (Igalmi™): Basic information

Should we use droperidol, which is available again?


Anti-Addiction medications

Acamprosate

Acamprosate (Campral®): Basic Information

Tips on using acamprosate for alcohol use disorder

Benzodiazepines for alcohol withdrawal

Which benzodiazepines for alcohol withdrawal syndrome (AWS)?

Benzodiazepine regimens for preventing or treating alcohol withdrawal

Buprenorphine

Buprenorphine (Subutex® and Suboxone®): Basic Information

Clinical pearls on prescribing buprenorphine (Suboxone®)

Clinical pearls about prescribing buprenorphine: Part Two

Disulfiram

Disulfiram—Why and How

How to use disulfiram to help with alcoholism

Disulfiram: A shortcut to sobriety?

Tips on offering disulfiram for alcohol use disorder


Disulfiram—Avoiding “hidden” sources of alcohol

Principles to help patients starting on disulfiram avoid hidden sources of alcohol

Specific tips to give to patients about how to avoid “hidden” alcohol in food and beverages

What are “non-alcoholic,” “alcohol-free,” “low alcohol,” and “reduced alcohol” beverages?

Where to find/ buy non-alcoholic or alcohol-free beer

Non-alcoholic or alcohol-free beer in patients with past alcohol use disorder?

Do we need to specifically tell persons with alcoholism to avoid drinking kombucha?

Recommend these alcohol-free mouthwash options to patients on disulfiram or with a dry mouth

Patients on disulfiram may appreciate being told about these alcohol-free options for fragrances


Disulfiram—Side Effects

How common is liver toxicity with disulfiram, and when does it occur?

When and how often should hepatic function tests be done in patients on disulfiram?

Naloxone

Special issues in using naloxone for overdoses involving fentanyl

YouTube video on how to use Evzio®

Naltrexone

Naltrexone (Revia®, Vivitrol®): Basic Information

Tips on using naltrexone for alcohol use disorder

How high can we go with naltrexone for alcohol use disorder?

What if a patient on naltrexone is in acute pain?

Does naltrexone cause insomnia OR does it cause sleepiness?


Naltrexone extended-release injectable (Vivitrol®)

Naltrexone (Revia®, Vivitrol®): Basic Information

Tips on using naltrexone extended-release injectable (Vivitrol®)

Could extended-release naltrexone injection work for alcohol use disorder even if oral naltrexone did not?

How to order, store, and administer naltrexone extended-release injection (Vivitrol®)

Find a Vivitrol® prescriber


Low-dose naltrexone (LDN)

What is low-dose naltrexone (LDN), and should it be used for anything?

Nicotine replacement therapy

A practical guide to nicotine replacement therapy (NRT)

How exactly should nicotine patches be used?

How exactly should nicotine gum be used?

How exactly should nicotine lozenges be used?

How exactly should nicotine oral inhalers be used?

How exactly should nicotine nasal spray be used?

Thiamine (for prevention of Wernicke-Korsakoff syndrome)

How exactly to prescribe thiamine for the prevention of Wernicke-Korsakoff syndrome

Varenicline

Are varenicline (Chantix) and bupropion safe for smoking cessation in persons with mental disorders?

Varenicline (Chantix®): Basic Information

A practical guide to using varenicline (Chantix®) for tobacco (smoking) cessation

What are the potential side effects of varenicline (Chantix®)?

Clarification about the potential neuropsychiatric side effects of varenicline (Chantix®)

Can varenicline (Chantix®) be stopped abruptly or should it be tapered off?

Other

How to learn addiction psychiatry

A practical guide to the management of tobacco use disorder

Do electronic cigarettes (e-cigarettes) work for smoking cessation?

What “authorities” say about e-cigarettes for tobacco use disorder 

What are electronic cigarettes (e-cigarettes)?

Clinical Institute Withdrawal Assessment for Alcohol, revised (CIWA-Ar)

Bupropion for cocaine use disorder?

APA Practice Guideline for the Pharmacological Treatment of Patients With Alcohol Use Disorder

Should we consider gabapentin for alcohol use disorder?


Antiamyloid antibodies

Antiamyloid antibodies—General articles

New, “disease-modifying” treatments for Alzheimer’s disease

Why amyloid-β and amyloid plaques are so important


Antiamyloid antibodies—Lecanemab

Untangling exactly whom lecanemab (Leqembi®) is FDA-approved for

How well does lecanemab (Leqembi®) work?

Should we recommend treatment with lecanemab (Leqembi®)?

Lecanemab (Leqembi®) carries an important boxed warning


Antiamyloid antibodies—Donanemab

A brief review of donanemab (Kisunla®) for Alzheimer’s disease


Anticholinergic medications

Should we routinely prescribe an anticholinergic with an antipsychotic?

Anticholinergic medications prescribed by mental health clinicians: Menu of options

Clinically important differences between anticholinergic medications

For how long should anticholinergics be given for antipsychotic-induced parkinsonism?

After a few months, try to reduce/ stop anticholinergic medication

How does toxicity from anticholinergic medications present clinically?

Cholinergic rebound syndrome: Why we should NOT stop anticholinergic medications abruptly

An anticholinergic medication for antidepressant discontinuation (withdrawal)?

Topical anticholinergics for localized hyperhidrosis


Beta-blockers

Clinical tips on using a beta-blocker for performance anxiety (“stage fright”)

Beta-blockers for panic disorder?

Akathisia: Treatment with a beta-blocker

Beta-blockers for lithium-induced benign tremor

What are the different types of beta-blockers?

Can beta-blockers cause depression or is this a myth?

CNS side effects of beta-blockers

Beta-blockers can either worsen or improve erectile dysfunction

Which beta-blockers in persons with diabetes?

Are beta-blockers contraindicated in asthma?


Bibliotherapy

Bibliotherapy: Recommend books to your patients and their families

BEST Books on Depressive disorders: for patients and families

BEST books on how to change habits

BEST books about how to lose weight

An Unquiet Mind

BEST books on Alzheimer’s disease and other dementias

BEST books on Adult Asperger’s Syndrome

Best books on adult ADHD: For patients and families

Book review: Mindfulness prescription for Adult ADHD

Book review: ADHD-Friendly Ways to Organize Your Life

Best book for choosing a rehab


  Cholinesterase Inhibitors—see Cognitive Enhancers


Cognitive Enhancers

Cholinesterase Inhibitors

Alzheimer’s disease: Medications

How to choose a cholinesterase inhibitor

Switch cholinesterase inhibitors?

Medications for dementia: Alternative preparations

What is benzgalantamine (Zunveyl®) and how is it different?

Donepezil (Aricept®, Aricept ODT®): Basic Information

Galantamine (Razadyne, Razadyne ER): Basic Information

Rivastigmine (Exelon®, Exelon® Patch): Basic Information

In what situations should we STOP cholinesterase inhibitors in patients with dementia?

Memantine

Memantine (Namenda®, Namenda XR®): Basic Information


Digital therapeutics

What is NightWare and should we recommend it to persons with nightmares?


Dopamine Agonists

Dopamine agonists—General articles

Can a dopamine agonist (pramipexole, ropinirole) and a stimulant be combined?

Dopamine agonist withdrawal syndrome (DAWS)

Pramipexole

Pramipexole: Basic information

Pramipexole for major depressive disorder or bipolar depression

Tips on using pramipexole for mood disorders

Potential adverse effects of pramipexole

Can a dopamine agonist (pramipexole, ropinirole) and a stimulant be combined?

Important! Dopamine agonist withdrawal syndrome (DAWS)

Ropinirole

Can a dopamine agonist (pramipexole, ropinirole) and a stimulant be combined?

Ropinirole (Requip®, Requip XL®) for major (unipolar) depression or bipolar depression?

Important! Dopamine agonist withdrawal syndrome (DAWS)


GABA-A positive modulators

Zuranolone (Zurzuvae™): Key facts

Brexanolone (brand name Zulresso®): Key facts


  Hypnotic Medications


Ketogenic diet and psychotropic medications

Ketogenic diet and amphetamines

Ketogenic diet and topiramate

Ketogenic diet and valproate


Medications for treating feeding and eating disorders

Lisdexamfetamine (Vyvanse®) for binge-eating disorder


Medications for treating obsessive-compulsive and related disorders

SSRIs for OCD

Higher than usual doses of SSRIs for OCD?

SSRIs for OCD: How high can we go?

Clomipramine versus SSRIs for OCD

Add clomipramine to an SSRI for OCD?

Concerns about combining clomipramine and SSRIs

How exactly to add clomipramine to an SSRI

When and how to check the clomipramine level

How to interpret clomipramine and desmethylclomipramine levels

OCD: Second-line medications

Antipsychotic “augmentation” for OCD

Is fluvoxamine more effective for OCD than other SSRIs?

N-acetylcysteine (NAC) for obsessive-compulsive disorder (OCD)?

Poor man’s vortioxetine

Body Dysmorphic Disorder: Pharmacological treatment

How to use serotonin reuptake inhibitors to treat body dysmorphic disorder

How to treat excoriation (skin picking) disorder: Pharmacological treatment


Medications for treating sexual dysfunction

General

Beta-blockers can worsen or improve erectile dysfunction

Cyproheptadine (Periactin®) for antidepressant-induced sexual dysfunction (ADISD)?

Which antidepressant for the treatment of premature ejaculation?

Treatment of premature ejaculation with antidepressants—daily or as-needed?

Flibanserin

Flibanserin (Addyi®)

Flibanserin (Addyi®) in postmenopausal women

Flibanserin (Addyi®): Basic information

Flibanserin (Addyi®): Systematic list of references

Phosphodiesterase-5 inhibitors (PDE-5 inhibitors)

Which PDE-5 inhibitor for erectile dysfunction?


Medications for treating trauma and stress-related disorders

Does prazosin work for PTSD? If so, for which symptoms?

How exactly should we dose prazosin in PTSD?

Warning! Prazosin can lead to hypotension/ syncope after the first dose

PTSD-associated nightmares: Menu of treatment options

Are psychostimulant medications contraindicated in persons with PTSD?


Melatonin receptor agonists

Melatonin

Melatonin: An introduction

Does melatonin work for insomnia?

Low-dose preparations of melatonin

Which brand and preparation of melatonin to recommend

Melatonin agonists for preventing and treating delirium?

What are the potential side effects of melatonin?

Does melatonin need to be gradually tapered off when stopping it?

Can melatonin have negative effects on puberty?  

Can melatonin increase blood sugar?

What drug interactions can occur with melatonin?

Ramelteon

Pros and cons of ramelteon (Rozerem) as a hypnotic

Ramelteon (Rozerem®): Basic Information

Miscellaneous

Melatonin agonists for preventing and treating delirium?

Melatonin agonists for sundowning in major neurocognitive disorder (dementia)?


Mood Stabilizers

Mood stabilizers—General articles

How many days to wait before measuring the blood level of any medication

When to measure serum levels of mood stabilizers

Combination therapy (mood stabilizer plus antipsychotic) for acute mania?

A practical guide to the management of bipolar disorders with mixed features

Does gabapentin work for bipolar disorder?

 Encourage pregnant women on an antiepileptic drug to enroll in these registries

Carbamazepine and Oxcarbazepine

Carbamazepine

Carbamazepine (Equetro®, Tegretol®-XR): Basic Information

Carbamazepine for neuropsychiatric symptoms in persons with dementia?

How should carbamazepine be discontinued?

What to do about contraception in women on carbamazepine or oxcarbazepine

HLA antigens and psychotropic drugs


Oxcarbazepine

Does oxcarbazepine (Trileptal®) work?

Advantages and Disadvantages of Trileptal® (oxcarbazepine) versus Tegretol® (carbamazepine)

How to start, titrate, and dose oxcarbazepine (Trileptal®)

Oxcarbazepine (Trileptal®): Plasma levels

What to do about contraception in women on carbamazepine or oxcarbazepine

Divalproex (or valproate or valproic acid)

How to prescribe divalproex

Also see: Mood stabilizers—General articles

Divalproex (Depakote®, Depakote ER®): Basic Information

Divalproex (Depakote®) or valproic acid (Depakene®) preparations

Divalproex (valproate) loading dose

What lab tests should we do in patients on divalproex (Depakote)?

All about when and how to order a FREE valproic acid level?

What is the optimal serum valproic acid (valproate) level?

Ketogenic diet and valproate

How to add valproate to lamotrigine

Efficacy of divalproex for different conditions

Does divalproex (valproate) work for bipolar depression?

Valproate for neuropsychiatric symptoms in dementia?

Side effects of divalproex

Valproate and hair loss (alopecia)

Valproate-induced pancreatitis

False-positive elevation of plasma ammonia

Valproate (Depakote®) and elevated serum ammonia level (hyperammonemia)

L-carnitine (levocarnitine; Carnitor®): Basic information

What to do if a patient develops thrombocytopenia during treatment with valproate 

Drug interactions of divalproex

Think twice before adding topiramate to valproate

Lamotrigine

Lamotrigine—General articles

Lamotrigine (Lamictal®): Basic Information

Can lamotrigine monotherapy be used for maintenance treatment in bipolar I disorder?

Lamotrigine: No additional benefit at 400 mg per day?

Why don’t we routinely prescribe lamotrigine extended-release (Lamictal XR®)?

How to add valproate to lamotrigine

Tips on using lamotrigine for mood disorders: Interview with Dr. Nassir Ghaemi


Lamotrigine—How to start

How to start and titrate lamotrigine (Lamictal®)

Dermatological precautions when starting lamotrigine


Lamotrigine—How to restart

Restarting lamotrigine

If lamotrigine is missed for a few days

Restarting lamotrigine: how many days?

Restarting lamotrigine: A case study


Lamotrigine—Medication levels

Lamotrigine level and adverse effects

Timing of blood draw for a serum lamotrigine level 

How many days to wait before checking a steady-state lamotrigine level


Lamotrigine—Skin rash

Dermatological precautions when starting lamotrigine

Is it a benign or dangerous skin rash?

How common are benign and serious rashes with lamotrigine?

Lamotrigine rechallenge after a skin rash?

Can “additive effects” increase the risk of Stevens-Johnson Syndrome (SJS) with lamotrigine?


Lamotrigine—Side effects (other than skin rash)

Can lamotrigine levels predict adverse effects? 

What to do about the risk of arrhythmias with lamotrigine

Can lamotrigine cause psychiatric side effects?

Can lamotrigine cause memory impairment?

Can lamotrigine cause bruising?

Is the use of lamotrigine during pregnancy safe?

Oral sores in a patient on lamotrigine 


Lamotrigine—Drug interactions

5 Action Items about OCs and lamotrigine

Does lamotrigine decrease the effectiveness of oral contraceptives?

How to reduce lamotrigine when an inducer is stopped

Folic acid may counteract the benefit of lamotrigine

Can “additive effects” increase the risk of Stevens-Johnson Syndrome (SJS) with lamotrigine?

Lithium

Lithium: Therapeutic use

Also see: Mood stabilizers—General articles

How to know who will respond better to lithium

Lithium: In how many doses per day?

“Simple and Practical” patient education about lithium

Is the extended-release preparation of lithium carbonate better?

Should we prescribe low-dose lithium?

What does this study tell us about the renal safety of immediate- versus prolonged-release lithium?

Lithium augmentation in major depressive disorder: How much?

Lithium augmentation in major depressive disorder: How long

Let’s not stop lithium abruptly or rapidly

If serum lithium levels vary unexpectedly, consider these possible causes

Should lithium be temporarily stopped before a colonoscopy?

How to manage lithium treatment before and after bariatric surgery

When and how to prescribe lithium citrate oral solution

What should we tell patients who ask about lithium orotate?


Lithium: Side effects and their management

Lithium toxicity

Clinical tips for identifying lithium toxicity clinically


Lithium: Hyperparathyroidism

Lithium induced hyperparathyroidism

How to screen for lithium-induced hyperparathyroidism

Lithium-induced hyperparathyroidism: Management

How to calculate corrected serum calcium

Sensipar® (cinacalcet) Prescribing Information


Lithium: Hypothyroidism

An introduction to lithium-induced hypothyroidism

How common is lithium-induced hypothyroidism?

How should lithium-induced hypothyroidism be evaluated?

How should lithium-induced hypothyroidism be managed?


Lithium: Renal impairment

Lithium-induced renal impairment: Clinical recommendations

Case: Rising serum creatinine in a patient on lithium

Case: Elevated serum creatinine that remained stable for many years

Is the extended-release preparation of lithium carbonate better?

Which preparation of lithium is less likely to harm the kidneys?

Lithium-induced polyuria and diabetes insipidus

Lithium-induced polyuria and diabetes insipidus: Evaluation

Lithium-induced polyuria and diabetes insipidus: Treatment

24-hour urine for creatinine clearance

How to collect a 24-hour urine sample


Lithium: Skin/ hair-related side effects

All about lithium-induced hair loss

Acne is a potential side effect of lithium

Lithium and psoriasis


Lithium: Tremors

Lithium-induced benign tremor: Introduction

Lithium-induced benign tremor: Evaluation

Lithium-induced benign tremor: Treatment

Beta-blockers for lithium-induced benign tremor

Vitamin B6 for lithium-induced benign tremor?


Lithium: Miscellaneous

Lithium’s effects on the electrocardiogram (ECG, EKG)

Tips on using lithium for bipolar disorder during pregnancy


Lithium: Drug interactions

Lithium and antihypertensives: Be careful!

Topiramate

Warning! Topiramate can cause kidney stones

Ketogenic diet and topiramate

Can we use topiramate to treat medication-induced weight gain?

Think twice before adding topiramate to valproate


Muscarinic agonist

Xanomeline+Trospium (Cobenfy™)

The rationale for xanomeline+trospium (Cobenfy™), approved for the treatment of schizophrenia

Efficacy of xanomeline+trospium (Cobenfy™) and comparison with second-generation antipsychotics

Xanomeline+trospium (Cobenfy™): Side effects


Psychedelics

Considerable beneficial effects are reported by psilocybin users

What side effects can psilocybin have?

Can psilocybin lead to suicide or other self-harm?

Is psilocybin addictive?

Can psychedelics cause serotonin toxicity (syndrome)?

Can a psychedelic be taken along with lithium?

What we need to know about hallucinogen persisting perception disorder (HPPD)


 Stimulant (Psychostimulant) Medications


Thyroid hormones

Thyroid hormones for psychopharmacologists: What’s what 

Pros and cons of liothyronine (T3) and levothyroxine (T4)

Levothyroxine (T4) for augmentation of antidepressants? 

Thyroid hormone for adjunctive treatment (augmentation) with an SSRI?

Liothyronine (T3) adjunctive treatment: How much and for how long?

Which thyroid hormone to use if one is needed for lithium-induced hypothyroidism


Vesicular monoamine transporter 2 (VMAT2) Inhibitors

Deutetrabenazine

Deutetrabenazine (Austedo®): Basic Information

Valbenazine

Valbenazine (Ingrezza®) and VMAT2

Valbenazine (Ingrezza®): Basic information

General

VMAT2 inhibitor? What’s that?

Comparing the VMAT2 inhibitors


Vitamins and Minerals

Multivitamin/ multimineral

Do’s and don’ts for taking a multivitamin

Which vitamins might cause harm even in commonly used doses?

Daily Value (DV) for vitamins and minerals

Biotin

When to consider recommending biotin supplementation

Biotin can interfere with many laboratory tests—and lead to serious misdiagnosis

C-reactive protein

A primer on C-reactive protein

C-reactive protein and mental disorders

Why does this patient have elevated homocysteine and C-reactive protein?

Iron

Instructions for WHEN and HOW to take iron supplements

Which foods are rich in iron?

How to maximize absorption of iron supplements 

Laboratory testing to identify iron deficiency

What is the best single test for checking the body’s iron stores?

How to order and interpret iron studies

Are we missing iron deficiency without anemia?

Let’s ask about heavy menstrual bleeding

How to improve the tolerability of iron supplementation

Iron deficiency, pica, and restless legs syndrome associated with blood donation

Restless Legs Syndrome (RLS) and iron deficiency

Magnesium

Basic facts about magnesium for mental health clinicians

Commonly used medications that can cause magnesium deficiency

Magnesium supplement for suspected alcohol/ medication-induced deficiency?

Which type of magnesium supplement to recommend

When should we worry that our patient is taking too much magnesium?

Vitamin B6

MAO inhibitors can affect vitamin B6 (pyridoxine)

Vitamin B6 (pyridoxine) for lithium-induced benign tremor?

Vitamin B12

How to evaluate a person’s vitamin B12 status 

Vitamin B12 and mental health 

Testing for B vitamins in persons with cognitive impairment

A patient with a low vitamin B12 level

Which supplements to recommend with a vegetarian or vegan diet

Elevated vitamin B12 levels are common and could be very serious

What laboratory tests to order to fully evaluate for possible vitamin B12 deficiency

Which diagnosis codes to use when ordering a vitamin B12 level

Vitamin D

What is vitamin D?

Do this before checking vitamin D levels or recommending supplementation

How should vitamin D status be measured?

Don’t order the test “calcitriol (1, 25-dihydroxy vitamin D)”

How to interpret the results of testing for vitamin D deficiency

How should we define vitamin D insufficiency (deficiency)?

How should vitamin D insufficiency or deficiency be treated?

Does vitamin D supplementation increase the risk of kidney stones?

Ultraviolet A and B: Implications for vitamin D production

Can vitamin D treat clinical depression?

Who is at higher risk for vitamin D deficiency?

Vitamin E

Vitamin E: A primer for clinicians

Does vitamin E work for tardive dyskinesia?

Vitamin E: Potential adverse effects and drug interactions

Vitamins and Minerals—Other Articles

Which vitamin supplements should we be cautious about recommending?

Kosher medications, vitamins, and supplements: Specific products

Also see: L-methylfolate, folate, and related compounds


Wakefulness-promoting agents

Armodafinil

Do modafinil/ armodafinil need cardiovascular monitoring

Armodafinil (Nuvigil®): Basic Information

Modafinil

Modafinil for ADHD?

Modafinil as an adjunct for major depressive disorder?

Do modafinil/ armodafinil need cardiovascular monitoring

Modafinil (Provigil®): Basic Information

Solriamfetol

Solriamfetol (Sunosi®): Basic Information


Weight-loss medications and treatments

Overview

Why it is important to treat obesity

Medications for weight loss?

Medications for the treatment of obesity: Overview


Naltrexone and bupropion

Bupropion plus naltrexone (Contrave®): Basic information

A generic alternative to naltrexone/bupropion (Contrave®)?

Does naltrexone alone work to produce weight loss?


Metformin

Metformin to prevent or treat metabolic adverse effects due to antipsychotics

Who is more likely to benefit from metformin for the management of metabolic adverse effects?

Metformin for antipsychotic-induced weight gain in children and adolescents?

Potential adverse effects of metformin

Tips on prescribing metformin

Metformin AND topiramate for metabolic adverse effects?

Metformin for weight gain or obesity unrelated to antipsychotic medications?

Should we start metformin at the same time as an antipsychotic?

Consider starting metformin, if it is needed, in inpatients on an antipsychotic


GLP-1 Receptor Agonists—Therapeutic Use

A simple primer on what GLP-1 agonists are

Semaglutide injection (Wegovy®) for weight loss in obesity and overweight

Does tirzepatide (Zepbound®) produce *even more* weight loss than semaglutide (Wegovy®)?

Will patients regain weight after GLP-1 receptor agonists are stopped?

GLP-1 receptor agonists in patients on antipsychotic medications?

GLP-1 receptor agonists may reduce alcohol craving/ use

GLP-1 receptor agonists for binge eating?

Semaglutide injection (Wegovy®): Basic information

Tirzepatide (Zepbound®): Basic information


GLP-1 Receptor Agonists—Side Effects

Semaglutide injection (Wegovy®): Side effects

Tips for reducing or managing nausea/ vomiting associated with GLP-1 agonists

What to tell patients about lean muscle loss due to GLP-1RAs and GIP/GLP-1RAs

Semaglutide injection (Wegovy®): Serious side effects, warnings, and contraindications

Are GLP-1 receptor agonists associated with an increased risk of suicidal ideation/ behavior?

Could the GLP-1 receptor agonist be causing your patient’s insomnia?

GLP-1 receptor agonists may worsen eating disorders or precipitate disordered eating


Orlistat

Orlistat (Xenical®): Basic Information


Phentermine

Phentermine (Adipex-P®, Lomaira™): Basic information

Phentermine-topiramate combination (Qsymia) for weight loss


Phentermine and topiramate

Phentermine and topiramate extended-release (Qsymia®): Basic Information


Topiramate

Can we use topiramate to treat medication-induced weight gain?

Metformin AND topiramate for metabolic adverse effects?


Bariatric surgery

What to do about psychotropic medications after bariatric surgery

How to manage lithium treatment before and after bariatric surgery

Is bupropion sustained-release OK to use after bariatric surgery?

Why and how to monitor and evaluate for suicide risk after bariatric surgery

Why, who, and how to monitor for increased alcohol use after bariatric surgery


Cost of Medications

How to find out the price of medications, compare prices, and get the lowest possible price

Tips on reducing the cost of medications by using higher-strength pills

Should we encourage patients to use independent pharmacies?

A simple way to significantly reduce the cost of l-methylfolate (Deplin®)


Prescription drug plans

What is the procedure for obtaining an early medication refill?

Prior authorization for medications

Pharmacy benefit managers


Online pharmacies

Should we recommend Costplusdrugs.com for lowering the cost of medications?

Medication prices on Costco.com versus on Goodrx.com

Can patients who have Medicare Part D use GoodRx coupons or CostPlusDrugs.com?

Medications from Canadian pharmacies?

Using a Canadian pharmacy can reduce the cost of some medications


Formulations of medications

Formulations of medications—General articles

Abbreviations for controlled-release formulations are out of control!

Antidepressants: What are the alternatives to the oral route?


Formulations of medications—Capsules

Do sustained-release preparations have fewer adverse effects?

Extended-release preparations of psychotropic medications

Can extended-release capsules be opened?

When a patient has difficulty getting off venlafaxine

How can duloxetine be tapered very slowly?

Two patients for whom opening medication capsules was helpful


Formulations of medications—Tablets

Are bupropion SR and bupropion ER the same thing?

Why, when, and how to split medication tablets

Recommended pill cutters and pill crushers

Which tablets are actually extended-release formulations and so should not be cut?

What if patients report seeing intact pills in their stools?


Formulations of medications—Orally disintegrating tablets (ODTs)

Orally disintegrating tablets (ODT) can be useful

Tips on using clonazepam orally disintegrating tablets (ODT)


Formulations of medications—Sublingual

Psychotropic medications are sometimes given sublingually


Formulations of medications—Liquids

Which antidepressants come in liquid forms?


Inactive Ingredients (Excipients) in Medications

Gluten in medications

Can lactose in medication pills cause intolerance?

How to find out whether a medication contains ingredients of animal origin


Generic medications

Are generic medications really equivalent to brand-name medications?

Generic and “authorized generic” medications

Which manufacturers of generic versions of psychotropic medications are better or worse?

Which generics of Concerta® (methylphenidate extended-release) to recommend

Is generic bupropion as effective as brand-name Wellbutrin®?

Can generic dextromethorphan and bupropion be used instead of the brand-name combination?

A generic alternative to naltrexone/bupropion (Contrave®)?


Laws and Regulations About Medications

Laws about prescriptions for psychostimulants

Can I take my medication with me when I travel to another country?

What patients taking a stimulant medication must know before visiting Japan


Off-Label Prescribing

We prescribe “off-label” more often than we think

Important! Off-label prescribing is of many different types

Off-label prescribing: Clinical recommendations


Pharmacodynamics and Pharmacokinetics

Which medications are mostly excreted unchanged, and why is this important?

Some medications have a low “therapeutic index”. What exactly is that?

Psychiatric medications with a long half-life

ABCB1 polymorphisms and psychotropic medications

Why is dextromethorphan combined with a CYP 2D6 inhibitor?

What does the Ki (inhibition constant) for a drug mean?

A simple guide to serotonin receptors

Dopamine receptors: A primer for clinicians

Melanocortin 4 receptor (MC4R) and weight gain


Miscellaneous articles

What to do about old prescriptions

Short answers to questions from our Members

Can persons on psychotropic medications donate blood?

What do the es-, the levo-, and the dex- mean in drug names?

Flibanserin (Addyi®)

Milnacipran (Savella®): Basic Information

What to do about psychiatric medications during the month of Ramadan


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Disclaimer: The material on this website is provided as general education for medical professionals. It is not intended for patients or other laypersons, nor is it a substitute for medical advice, diagnosis, or treatment. Patients must always consult a qualified healthcare professional regarding their diagnosis and treatment. Healthcare professionals should always check this website for the most up-to-date information.

Comments

  1. Shira Rubinstein says

    November 6, 2023 at 9:12 pm

    What articles do you have on treatments for perimenopausal mood and vasomotor symptoms?
    Specifically I am looking for article on SSRIs and SNRIs and other non-hormonal options.
    Many thanks

    • Rajnish Mago, MD says

      November 12, 2023 at 5:27 pm

      I went to our Main Menu for “Disorders/ Conditions” and, in that Menu, to the category of “Women’s mental health”. It showed that we have the following two articles about perimenopausal symptoms and their treatment:

      Tips on managing perimenopausal symptoms

      Adjunctive estrogen for perimenopausal depression?

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