Pramipexole may be an off-label option for major depressive disorder or bipolar depression that has not responded to several treatments. What is pramipexole? Pramipexole (US brand name Mirapex®, Mirapex ER®, and generic) is an agonist of the dopamine D2 receptor family. The D2 receptor family consists of the D2, D3, and D4 receptors. However, pramipexole…