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Flibanserin (Addyi®): Basic Information

Flibanserin (US brand name Addyi®) is a serotonin 1A receptor agonist and a serotonin 2A receptor antagonist. The exact mechanism of action of flibanserin is unknown. Here is basic information about this medication.


FDA-approved indications

Treatment of premenopausal women with acquired, generalized hypoactive sexual desire disorder (HSDD) as characterized by low sexual desire that causes marked distress or interpersonal difficulty and is NOT due to:

  • A co-existing medical or psychiatric condition
  • Problems within the relationship or
  • The effects of a medication or other drug substance

Dosage

Recommended: 100 mg orally taken once daily at bedtime

Discontinue treatment after 8 weeks if no improvement


Contraindications

  • Alcohol (deleted on April 13, 2019)
  • Moderate or strong cytochrome P450 3A4 (CYP3A4) inhibitors
  • Hepatic impairment

Dosage forms and strengths (USA)

Tablet: 100 mg


Important! Please refer to the full Prescribing Information (see link below) before prescribing this medication.


Related Pages

Flibanserin (Addyi®)

Flibanserin (Addyi®): Systematic list of references

Sexual dysfunction

Arizona Sexual Experiences Scale (ASEX)

What are the BEST books on each topic related to psychiatry/ mental health?


References

Prescribing information for flibanserin (Addyi®)


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