Modafinil (US brand name Provigil® and generic) is a wakefulness promoting agent. Here is key information about this medication.
FDA-approved indications
To improve wakefulness in adult patients with narcolepsy, obstructive sleep apnea (OSA), or shift work disorder (SWD)
Dosage
1. Adults
Narcolepsy or OSA: 200 mg once daily in the morning
Shift work disorder: 200 mg once a day taken approximately one hour prior to start of the work shift
2. Geriatric patients
Consider lower dose
3. Patients with severe hepatic impairment
Reduce to half the recommended dose
Dosage forms and strengths
Tablets: 100 mg and 200 mg (scored)
Please refer to Prescribing Information (see link below) for complete discussion of dosage, administration, warnings and precautions, contraindications, etc.
Cytochrome P450 drug interactions
Modafinil is an inhibitor of CYP 2C19.
It is also an inducer of CYP 1A2 and CYP 3A4
Related Pages
Armodafinil (Nuvigil®): Basic Information
How to screen for sleep apnea: Main page
How to know if your patient snores if s/he sleeps alone!
Sleep Disorders: Index and Links
Other Psychiatric Medications: Index and Links
Pyschopharmacology: Index and Links
References
Prescribing Information for Modafinil (Provigil®)
Copyright 2016, Rajnish Mago, MD. All rights reserved. May not be reproduced in any form without express written permission.
Disclaimer: The content on this website is provided as general education for medical professionals. It is not intended or recommended for patients or other laypersons, or as a substitute for medical advice, diagnosis, or treatment. Patients must always consult a qualified health care professional regarding their diagnosis and treatment. Healthcare professionals should always check this website for the most recently updated information.
Leave a Reply