Modafinil (US brand name Provigil® and generic) is a wakefulness promoting agent. Here is key information about this medication.
To improve wakefulness in adult patients with narcolepsy, obstructive sleep apnea (OSA), or shift work disorder (SWD)
Narcolepsy or OSA: 200 mg once daily in the morning
Shift work disorder: 200 mg once a day taken approximately one hour prior to start of the work shift
2. Geriatric patients
Consider lower dose
3. Patients with severe hepatic impairment
Reduce to half the recommended dose
Dosage forms and strengths
Tablets: 100 mg and 200 mg (scored)
Please refer to Prescribing Information (see link below) for complete discussion of dosage, administration, warnings and precautions, contraindications, etc.
Cytochrome P450 drug interactions
Modafinil is an inhibitor of CYP 2C19.
It is also an inducer of CYP 1A2 and CYP 3A4
Copyright 2016, Rajnish Mago, MD. All rights reserved. May not be reproduced in any form without express written permission.
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