Modafinil (US brand name Provigil® and generic) is a wakefulness-promoting agent. Here is basic information about this medication. Other articles on this website with more advanced information and tips related to this medication are linked to under Related Pages below.
To improve wakefulness in adult patients with narcolepsy, obstructive sleep apnea (OSA), or shift work disorder (SWD)
Narcolepsy or OSA: 200 mg once daily in the morning
Shift work disorder: 200 mg once a day, taken approximately one hour prior to the start of the work shift
2. Geriatric patients
Consider a lower dose
3. Patients with severe hepatic impairment
Reduce to half the recommended dose
Dosage forms and strengths
Tablets: 100 mg and 200 mg (scored)
Cytochrome P450 drug interactions
Modafinil is an inhibitor of CYP 2C19.
It is also an inducer of CYP 1A2 and CYP 3A4
Potential side effects
Please see THIS PAGE for a handout listing both the common and less common side effects of this medication along with the percentages of patients who report them.
Important! Please refer to the full Prescribing Information (see link below) before prescribing this medication.
Copyright 2016, Rajnish Mago, MD. All rights reserved. May not be reproduced in any form without express written permission.
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