What if one cholinesterase inhibitor is not effective or well-tolerated? Switching to another cholinesterase inhibitor can be helpful in up to 50% of such cases (O’Brien et al., 2017). References O’Brien JT, Holmes C, Jones M, Jones R, Livingston G, McKeith I, Mittler P, Passmore P, Ritchie C, Robinson L, Sampson EL, Taylor JP, Thomas…