Treatment of premature ejaculation with antidepressants—daily or as-needed?

Question from a Member: I saw a patient today who [takes] sertraline 25 mg weekly for premature ejaculation. I … don’t understand (unless it is placebo) how weekly dosing is going to help as the changes to the serotonin system take time to develop. Premature ejaculation is very common (Althof et al., 2014) and is…