Iloperidone (Fanapt®): Basic Information - Simple and Practical Mental Health

This article was last reviewed/ updated on January 17, 2023.

Iloperidone (US brand name Fanapt®) is a second-generation (“atypical”) antipsychotic. Here is basic information about this medication.

FDA-approved indications

Treatment of adults with schizophrenia.

The FDA indication statement also includes the following (emphasis added):

” In choosing among treatments, prescribers should consider the ability of FANAPT to prolong the QT interval and the use of other drugs first. Prescribers should also consider the need to titrate FANAPT slowly to avoid orthostatic hypotension, which may lead to delayed effectiveness compared to some other drugs that do not require similar titration.”

Dosage

Starting dose: 1 mg twice daily

Titration: The dose should then be increased to 2 mg, 4 mg, 6 mg, 8 mg, 10 mg, and 12 mg twice daily on days 2, 3, 4, 5, 6, and 7 respectively.

Target dose: 6 to 12 mg twice daily (achieved by dose increments of 1–2 mg twice daily)

Maximum dose: The recommended target dosage of iloperidone is 12 to 24 mg/day administered in two divided doses.

Please refer to Prescribing Information (see link below) for a complete discussion of dosage, administration, warnings and precautions, contraindications, etc.

Dosage forms and strengths

Tablets: 1 mg, 2 mg, 4 mg, 6 mg, 8 mg, 10 mg, and 12 mg

Second-generation (“atypical”) antipsychotics (List)

Second-generation antipsychotics: Dose equivalents

Antipsychotics and QT prolongation

Antibiotics, Antipsychotics, and QTc Prolongation

The patient who “demands” TWO antipsychotics

What should I be doing to monitor patients who are on an antipsychotic?

Main menu: Treatments

References

Iloperidone Prescribing Information

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