Is lumateperone really less likely to cause extrapyramidal symptoms (including parkinsonism or akathisia)?

This article was published on June 20, 2022. In another article on this website, we noted a few reasons why lumateperone’s pharmacological profile would lead us to expect it to be associated with a lower incidence of motor side effects. But, a lot of fancy explanations don’t pan out in human clinical trials. So, let’s…