Valbenazine (US Brand name Ingrezza®) is a vesicular monoamine transporter 2 (VMAT2) inhibitor. Here is basic information about this medication. Other articles on this website with more advanced information and tips related to this medication are linked to under Related Pages below.
Treatment of adults with tardive dyskinesia
The initial dose is 40 mg once daily orally. After one week, increase the dose to the recommended dose of 80 mg once daily.
Administration and instructions
Valbenazine may be administered with or without food.
In patients with moderate and severe hepatic impairment, the recommended dose is 40 mg daily.
Based on tolerability, consider dose reduction for known poor CYP2D6 metabolizers.
Dosage forms and strengths
Capsules: 40 mg and 80 mg
Valbenazine carries a warning about somnolence and about the risk of QT prolongation.
Potential side effects
Please see THIS PAGE for a handout listing both the common and less common side effects of this medication along with the percentages of patients who report them.
Valbenazine is metabolized by two pathways:
1. By hydrolysis to its active metabolite [+]-α-HTBZ. This active metabolite is then metabolized by CYP450 2D6
2. By oxidative metabolism (mainly by the CYP450 3A4/5 enzyme.
This is why dose reduction is recommended both in known CYP 450 2D6 poor metabolizers and in those on a strong inhibitor of CYP 3A4.
Important! Please refer to the full Prescribing Information (see link below) before prescribing this medication.
Copyright 2017, Rajnish Mago, MD. All rights reserved. May not be reproduced in any form without express written permission.
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