Deutetrabenazine (US brand name Austedo®) is a vesicular monoamine transporter 2 (VMAT2) inhibitor. Here is basic information about this medication. Other articles on this website with more advanced information and tips related to this medication are linked to under Related Pages below.
Treatment of chorea associated with Huntington’s disease
Treatment of tardive dyskinesia in adults
A. When patients are not being switched from tetrabenazine (Xenazine®)
1. Chorea associated with Huntington’s disease
Initial: 6 mg/day orally
Recommended: 6 mg – 48 mg/day
Maximum: 48 mg/day
2. Tardive dyskinesia
Initial: 12 mg/day
Recommended: 12 mg– 48 mg/day
Maximum: 48 mg/day
B. When patients are being switched from tetrabenazine (Xenazine®) to deutetrabenazine (Austedo®)[table id=3 /]
Titrate at weekly intervals by 6 mg per day based on reduction of chorea or tardive dyskinesia, and tolerability, up to a maximum recommended daily dosage of 48 mg (24 mg twice daily).
Administer total daily dosages of 12 mg or above in two divided doses.
Administer deutetrabenazine with food.
Patients should swallow whole tablets without chewing, crushing, or breaking tablets.
For patients at risk for QT prolongation, assess the QT interval before and after increasing total deutetrabenazine dosage above 24 mg per day
Dosage forms and strengths
Tablets: 6 mg, 9 mg, and 12 mg
Potential side effects
Please see THIS PAGE for a handout listing both the common and less common side effects of this medication along with the percentages of patients who report them.
Important! Please refer to the full Prescribing Information (see link below) before prescribing this medication.
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