Tranylcypromine (Parnate®) is a non-hydrazine monoamine oxidase (MAO) inhibitor. Here is some key information about this medication.
FDA-approved indications
Major depressive episode without melancholia
Tranylcypromine is an MAO inhibitor that has a structure that is chemically similar to amphetamine and it is, therefore, particularly stimulating. This fact is one of the key factors in deciding between phenelzine and tranylcypromine. Other factors that help decide which one of these two MAOIs to use are summarized in a simple table HERE.
Dosage
Usual: 30 mg/day (in divided doses)
Maximum: 60 mg/day (in divided doses)
Suggested titration schedule: Start with 10 mg/day. After 2 days, increase to 10 mg twice daily. After another 2 to 3 days, increase to 10 mg three times a day. Then increase by 10 mg/day every one to three weeks, if needed and tolerated, to a usual maximum of 60 mg/day.
Dietary Modifications
Avoid tyramine-rich foods or beverages, in combination with tranylcypromine, or within two weeks after stopping treatment.
Dosage forms and strengths
Tablets: 10 mg
Important! Please refer to the full Prescribing Information (see link below) before prescribing this medication.
Related Pages
Phenelzine (Nardil®) versus Tranylcypromine (Parnate®)
Switching from one MAOI to another
Monoamine oxidase inhibitors (MAOIs) and other medications
MAO Inhibitor diet
References
Parnate® Prescribing Information
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