Phenelzine and tranylcypromine are quite different in their effects. Here are some key differences between phenelzine and tranylcypromine that should be considered in choosing between these two medications.
|Phenelzine (Nardil®)||Tranylcypromine (Parnate®)|
|1.||Orthostatic hypotension more likely.|
|2.||B6 deficiency more likely|
|3.||More sedating||More stimulating (structurally similar to amphetamine)|
|4.||More weight gain|
|5.||More likely to cause edema|
|6.||More likely to cause cheese reaction|
Birkenhäger TK, van den Broek WW, Mulder PG, Bruijn JA, Moleman P. Efficacy and tolerability of tranylcypromine versus phenelzine: a double-blind study in antidepressant-refractory depressed inpatients. J Clin Psychiatry. 2004 Nov;65(11):1505-10. PubMed PMID: 15554763.
Rabkin J, Quitkin F, Harrison W, Tricamo E, McGrath P. Adverse reactions to monoamine oxidase inhibitors. Part I. A comparative study. J Clin Psychopharmacol. 1984 Oct;4(5):270-8. PubMed PMID: 6386898.
Rabkin JG, Quitkin FM, McGrath P, Harrison W, Tricamo E. Adverse reactions to monoamine oxidase inhibitors. Part II. Treatment correlates and clinical management. J Clin Psychopharmacol. 1985 Feb;5(1):2-9. PubMed PMID: 3973068.
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