How to choose between phenelzine (Nardil®) and tranylcypromine (Parnate®)? Here are the key differences:
|Phenelzine (Nardil®)||Tranylcypromine (Parnate®)|
|1.||Orthostatic hypotension more likely.|
|2.||B6 deficiency more likely|
|3.||More sedating||More stimulating (structurally similar to amphetamine)|
|4.||More weight gain|
|5.||More likely to cause edema|
|6.||More likely to cause cheese reaction|
Birkenhäger TK, van den Broek WW, Mulder PG, Bruijn JA, Moleman P. Efficacy and tolerability of tranylcypromine versus phenelzine: a double-blind study in antidepressant-refractory depressed inpatients. J Clin Psychiatry. 2004 Nov;65(11):1505-10. PubMed PMID: 15554763.
Rabkin J, Quitkin F, Harrison W, Tricamo E, McGrath P. Adverse reactions to monoamine oxidase inhibitors. Part I. A comparative study. J Clin Psychopharmacol. 1984 Oct;4(5):270-8. PubMed PMID: 6386898.
Rabkin JG, Quitkin FM, McGrath P, Harrison W, Tricamo E. Adverse reactions to monoamine oxidase inhibitors. Part II. Treatment correlates and clinical management. J Clin Psychopharmacol. 1985 Feb;5(1):2-9. PubMed PMID: 3973068.
Copyright 2015, Rajnish Mago, MD. All rights reserved. May not be reproduced in any form without express written permission.
Disclaimer: The content on this website is provided as general education for medical professionals. It is not intended or recommended for patients or other lay persons or as a substitute for medical advice, diagnosis, or treatment. Patients must always consult a qualified health care professional regarding their diagnosis and treatment. Healthcare professionals should always check this website for the most recently updated information.