Tranylcypromine (Parnate®) is a non-hydrazine monoamine oxidase (MAO) inhibitor. Here is some key information about this medication.
Major depressive episode without melancholia
Tranylcypromine is an MAO inhibitor that has a structure that is chemically similar to amphetamine and it is, therefore, particularly stimulating. This fact is one of the key factors in deciding between phenelzine and tranylcypromine. Other factors that help decide which one of these two MAOIs to use are summarized in a simple table HERE.
Usual: 30 mg/day (in divided doses)
Maximum: 60 mg/day (in divided doses)
Suggested titration schedule: Start with 10 mg/day. After 2 days, increase to 10 mg twice daily. After another 2 to 3 days, increase to 10 mg three times a day. Then increase by 10 mg/day every one to three weeks, if needed and tolerated, to a usual maximum of 60 mg/day.
Avoid tyramine-rich foods or beverages, in combination with tranylcypromine, or within two weeks after stopping treatment.
Dosage forms and strengths
Tablets: 10 mg
Important! Please refer to the full Prescribing Information (see link below) before prescribing this medication.
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