Paliperidone extended-release (US brand name Invega® and generic) is a second-generation (“atypical”) antipsychotic. Here is basic information about this medication.
FDA-approved indications
1. Treatment of schizophrenia in adults and adolescents (ages 12-17)
2. Treatment of schizoaffective disorder in adults as monotherapy and as an adjunct to mood stabilizers and/or antidepressants.
Dosage
A. Schizophrenia (adults)
Initial: 6 mg/day
Recommended: 3 – 12 mg/day
Maximum: 12 mg/day
Recommended dose increments: 3 mg/day at intervals of more than 5 days after clinical assessment
Dose increases above 6 mg/day should be made only after clinical reassessment and generally should occur at intervals of more than 5 days
B. Schizophrenia (adolescents < 51 kg)
Initial: 3 mg/day
Recommended: 3 – 6 mg/day
Maximum: 6 mg/day
Recommended dose increments: 3 mg/day at intervals of more than 5 days after clinical assessment
C. Schizophrenia (adolescents ≥ 51 kg)
Initial: 3 mg/day
Recommended: 3 – 12 mg/day
Maximum: 12 mg/day
Recommended dose increments: 3 mg/day at intervals of more than 5 days after clinical assessment
d. Schizoaffective Disorder (adults)
Initial: 6 mg/day
Recommended: 3 – 12 mg/day
Maximum: 12 mg/day
Recommended dose increments: 3 mg/day at intervals of more than 4 days after clinical assessment
Paliperidone should be administered once daily. Tablets should be swallowed whole and should not be chewed, divided, or crushed.
Dosage forms and strengths
Tablets: 1.5 mg, 3 mg, 6mg, and 9 mg
Please refer to Prescribing Information (see link below) for a complete discussion of dosage, administration, warnings and precautions, contraindications, etc.
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Second-generation (“Atypical”) antipsychoticsA
References
Prescribing information for paliperidone extended-release (Invega®)
Copyright 2015, Rajnish Mago, MD. All rights reserved. May not be reproduced in any form without express written permission.
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