Paliperidone palmitate (Invega Sustenna®) is an extended-release injectable second-generation (“atypical”) antipsychotic. Here is basic information about this medication.
- Treatment of schizophrenia
- Treatment of schizoaffective disorder as monotherapy and as an adjunct to mood stabilizers or antidepressants
Initiation (IM deltoid): Administer 234 mg on day 1; 156 mg on day 8
Monthly maintenance dose (IM deltoid or gluteal): 39–234 mg (administered 5 weeks after first injection)
Maximum monthly dose: 234 mg
(Recommended maintenance dose for schizophrenia is 117 mg, though some patients may benefit from higher or lower doses within available strengths)
B. Schizoaffective disorder
Initiation (IM deltoid): 234 mg on day 1; 156 mg on day 8
Monthly maintenance dose (IM deltoid or gluteal): 78–234 mg (based upon tolerability and efficacy)
Maximum monthly dose: 234 mg
C) Use in specific population: patients with renal impairment
Mild renal impairment (creatinine clearance 50-80 mL/min): Administer 156 mg on treatment day 1 and 117 mg one week later, both on deltoid muscle. Follow with monthly injections of 78 mg in either the deltoid or gluteal muscle.
Moderate to severe renal impairment (creatinine clearance<50 mL/min): Invega Sustenna® is not recommended
Dosage forms and strengths
Extended-release injectable suspension: 39 mg, 78 mg, 117 mg, 156 mg, and 234 mg
Important! Please refer to the full Prescribing Information (see link below) before prescribing this medication.
Dose equivalents of long-acting injectable second-generation antipsychotics
Equivalence of risperidone oral and long-acting injection (RLAI; Risperdal Consta®)
CPT billing code for administration of injections
Aripiprazole lauroxil (Aristada®) versus Aripiprazole (Abilify Maintena®)
Be careful in converting from Abilify Maintena® to Aristada®
Long-acting injectable antipsychotics: Overview
Aripiprazole (Abilify Maintena®): Basic information
Aripiprazole lauroxil (Aristada®): Basic information
Olanzapine (Zyprexa Relprevv®): Basic information
Paliperidone palmitate (Invega Sustenna®): Basic information
Paliperidone palmitate 3-month (Invega Trinza®): Basic information
Risperidone long-acting injection (Risperdal Consta®): Basic Information
Paliperidone palmitate (Invega Sustenna®) Prescribing Information
Copyright 2015, Rajnish Mago, MD. All rights reserved. May not be reproduced in any form without express written permission.
Disclaimer: The content on this website is provided as general education for medical professionals. It is not intended or recommended for patients or other laypersons, or as a substitute for medical advice, diagnosis, or treatment. Patients must always consult a qualified health care professional regarding their diagnosis and treatment. Healthcare professionals should always check this website for the most recently updated information.
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