This article was first published on December 23, 2022. It was last reviewed and updated on December 26, 2022.
Experienced (old? 🙂 ) clinicians who prescribe psychiatric medications to patients with so-called “treatment-resistant” depression are concerned that many younger clinicians have not been provided with the knowledge and skills that are necessary for being able to safely and effectively prescribe the classic MAO inhibitors (phenelzine, tranylcypromine, isocarboxazid).
One important step in providing guidance on this topic is the following paper that was published in 2022:
The prescriber’s guide to classic MAO inhibitors (phenelzine, tranylcypromine, isocarboxazid) for treatment-resistant depression.
(I am proud to be one of the many co-authors of this publication.)
This paper can be accessed and downloaded at no cost at the following link:
The guide is authored by a large international team of authors who are highly-respected psychopharmacology experts. That is why it is an important step toward building expert consensus about how to use the classic MAO inhibitors.
Classic MAO inhibitors
Classic MAO inhibitors—General
MAO inhibitors—Side effects
MAO inhibitors—Drug interactions
MAO Inhibitors and other medications (patient handout) (link to the handouts page)
Van den Eynde V, Abdelmoemin WR, Abraham MM, Amsterdam JD, Anderson IM, Andrade C, Baker GB, Beekman ATF, Berk M, Birkenhäger TK, Blackwell BB, Blier P, Blom MBJ, Bodkin AJ, Cattaneo CI, Dantz B, Davidson J, Dunlop BW, Estévez RF, Feinberg SS, Finberg JPM, Fochtmann LJ, Gotlib D, Holt A, Insel TR, Larsen JK, Mago R, Menkes DB, Meyer JM, Nutt DJ, Parker G, Rego MD, Richelson E, Ruhé HG, Sáiz-Ruiz J, Stahl SM, Steele T, Thase ME, Ulrich S, van Balkom AJLM, Vieta E, Whyte I, Young AH, Gillman PK. The prescriber’s guide to classic MAO inhibitors (phenelzine, tranylcypromine, isocarboxazid) for treatment-resistant depression. CNS Spectr. 2022 Jul 15:1-14. doi: 10.1017/S1092852922000906. Epub ahead of print. PMID: 35837681.
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