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Isocarboxazid (Marplan®): Basic Information

Isocarboxazid (Marplan®) is a non-selective hydrazine monoamine oxidase (MAO) inhibitor. Here is key information about this medication.

FDA-approved indications

Treatment-Resistant Depression

Dosage

Starting: 20 mg/day (in two divided doses)
End of 1st week: 40 mg/day
Maximum: 60 mg/day in 2-4 divided doses

After the starting dose, further increase may be in increments of 10 mg every 2-4 days to 40 mg at the end of first week, and then 20 mg/week until maximum of 60 mg/day, if needed and tolerated.

Once the maximal therapeutic response is achieved, an attempt should be made to decrease the dosage to the lowest effective level, over several weeks.

Dietary Modifications

Avoid tyramine rich foods or beverages, in combination with isocarboxazid, or within two weeks after stopping treatment.

Dose forms and strengths

Tablets: 10 mg

Please refer to Prescribing Information (see link below) for complete discussion of dosage, administration, warnings and precautions, contraindications, etc.


Related Pages

Switching from one MAOI to another

Monoamine oxidase inhibitors (MAOIs) and other medications

MAO Inhibitor diet

Antidepressants: Index and Links


References

Marplan® Prescribing Information


Copyright 2016, Rajnish Mago, MD. All rights reserved. May not be reproduced in any form without express written permission.

Disclaimer: The content on this website is provided as general education for medical professionals. It is not intended or recommended for patients or other laypersons, or as a substitute for medical advice, diagnosis, or treatment. Patients must always consult a qualified health care professional regarding their diagnosis and treatment. Healthcare professionals should always check this website for the most recently updated information.

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