Isocarboxazid (Marplan®) is a non-selective hydrazine monoamine oxidase (MAO) inhibitor. Here is key information about this medication.
FDA-approved indications
Treatment-Resistant Depression
Dosage
Starting: 20 mg/day (in two divided doses)
End of 1st week: 40 mg/day
Maximum: 60 mg/day in 2-4 divided doses
After the starting dose, further increase may be in increments of 10 mg every 2-4 days to 40 mg at the end of first week, and then 20 mg/week until maximum of 60 mg/day, if needed and tolerated.
Once the maximal therapeutic response is achieved, an attempt should be made to decrease the dosage to the lowest effective level, over several weeks.
Dietary Modifications
Avoid tyramine rich foods or beverages, in combination with isocarboxazid, or within two weeks after stopping treatment.
Dose forms and strengths
Tablets: 10 mg
Please refer to Prescribing Information (see link below) for complete discussion of dosage, administration, warnings and precautions, contraindications, etc.
Related Pages
Switching from one MAOI to another
Monoamine oxidase inhibitors (MAOIs) and other medications
MAO Inhibitor diet
Antidepressants: Index and Links
References
Marplan® Prescribing Information
Copyright 2016, Rajnish Mago, MD. All rights reserved. May not be reproduced in any form without express written permission.
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