Phenelzine (Nardil®) is a hydrazine derivative and an irreversible monoamine oxidase inhibitor (MAOI). Here is key information about this medication.
FDA-approved indications
“Atypical, non-endogenous, or neurotic depression not responding to other antidepressants.”
Dosage
Initial dose: 45 mg/day (in 3 divided doses)
Early phase treatment: 60 mg/day, up to a maximum of 90 mg/day
Maintenance dose: 15 mg per day or every other day (tapered over few weeks after maximal response is achieved)
Suggested titration schedule: Start with 15 mg/day. After 2 days, increase to 15 mg twice daily. After another 2 to 3 days, increase to 15 mg three times a day. Increase if needed by 15 mg/day every week to a usual maximum of 90 mg/day.
Dietary Modifications
Avoid tyramine rich foods or beverages, in combination with phenelzine, or within two weeks after stopping treatment.
Dose forms and strengths
Tablets: 15 mg
Please refer to Prescribing Information (see link below) for complete discussion of dosage, administration, warnings and precautions, contraindications, etc.
Related Pages
Phenelzine (Nardil®) versus tranylcypromine (Parnate®)
Switching from one MAOI to another
Monoamine oxidase inhibitors (MAOIs) and other medications
MAO Inhibitor diet
Antidepressants: Index and Links
References
Nardil® Prescribing Information
Copyright 2016, Rajnish Mago, MD. All rights reserved. May not be reproduced in any form without express written permission.
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