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Phenelzine (Nardil®): Basic Information

Phenelzine (Nardil®) is a hydrazine derivative and an irreversible monoamine oxidase inhibitor (MAOI). Here is key information about this medication.


FDA-approved indications

“Atypical, non-endogenous, or neurotic depression not responding to other antidepressants.”


Dosage

Initial dose: 45 mg/day (in 3 divided doses)

Early phase treatment: 60 mg/day, up to a maximum of 90 mg/day

Maintenance dose: 15 mg per day or every other day (tapered over few weeks after maximal response is achieved)

Suggested titration schedule: Start with 15 mg/day. After 2 days, increase to 15 mg twice daily. After another 2 to 3 days, increase to 15 mg three times a day. Increase if needed by 15 mg/day every week to a usual maximum of 90 mg/day.


Dietary Modifications

Avoid tyramine rich foods or beverages, in combination with phenelzine, or within two weeks after stopping treatment.


Potential side effects

Here are the common side effects of phenelzine as listed in the Prescribing Information:

Postural hypotension
Weight gain
Insomnia
Sexual disturbances
Edema
Dizziness
Headache
Drowsiness
Fatigue
Weakness
Tremors
Constipation
Dry mouth
Stomach disturbances
Elevated liver enzymes


Dose forms and strengths

Tablets: 15 mg

Please refer to Prescribing Information (see link below) for a complete discussion of dosage, administration, warnings and precautions, contraindications, etc.


Related Pages

Phenelzine (Nardil®) versus tranylcypromine (Parnate®)

Switching from one MAOI to another

Monoamine oxidase inhibitors (MAOIs) and other medications

MAO Inhibitor diet


References

Nardil® Prescribing Information


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