Phenelzine (Nardil®) is a hydrazine derivative and an irreversible monoamine oxidase inhibitor (MAOI). Here is key information about this medication.
“Atypical, non-endogenous, or neurotic depression not responding to other antidepressants.”
Initial dose: 45 mg/day (in 3 divided doses)
Early phase treatment: 60 mg/day, up to a maximum of 90 mg/day
Maintenance dose: 15 mg per day or every other day (tapered over few weeks after maximal response is achieved)
Suggested titration schedule: Start with 15 mg/day. After 2 days, increase to 15 mg twice daily. After another 2 to 3 days, increase to 15 mg three times a day. Increase if needed by 15 mg/day every week to a usual maximum of 90 mg/day.
Avoid tyramine rich foods or beverages, in combination with phenelzine, or within two weeks after stopping treatment.
Potential side effects
Here are the common side effects of phenelzine as listed in the Prescribing Information:
Elevated liver enzymes
Dose forms and strengths
Tablets: 15 mg
Please refer to Prescribing Information (see link below) for a complete discussion of dosage, administration, warnings and precautions, contraindications, etc.
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