Lumateperone (US brand name Caplyta™) is a second-generation (“atypical”) antipsychotic. Here is basic information about this medication.
Other articles on this website with more advanced information and tips related to this medication are linked to under Related Pages below.
Treatment of schizophrenia in adults.
Pharmacodynamics and Mechanism of action
The exact mechanism of action in the treatment of schizophrenia is unknown. But, it is hypothesized that lumateperone’s effects are mediated through antagonism (blocking) of the following two receptors in the brain:
– Postsynaptic dopamine D2 receptors
– Serotonin 5-HT2A receptors.
It has a high binding affinity for serotonin 5-HT2A receptors and a moderate binding affinity for dopamine D2 receptors.
Peak plasma concentration (Cmax)
After it is taken orally, the peak plasma concentration of lumateperone is reached approximately 1 to 2 hours later.
Ingestion of a high-fat meal with lumateperone may lower lumateperone peak plasma concentration by 33%.
About 97% of lumateperone is protein bound.
Half-life and steady-state
The terminal half-life of lumateperone is about 18 hours.
So, it reaches steady-state concentration after about 5 days.
Lumateperone is, obviously, contraindicated in patients who have had an allergic reaction to it.
Potential side effects
The most common side effects of lumateperone are:
– Sedation and
– Dry mouth.
Other potential side effects include:
– Increase in creatine phosphokinase
– Increase in hepatic transaminases
– Decreased appetite.
– No dose titration is required for lumateperone.
– Dose: 42 mg once daily.
– Lumateperone should be taken with food.
Dosage forms and strengths
Capsules: 42 mg
Important! Please refer to the full Prescribing Information (see link below) before prescribing this medication.
Copyright 2020 to 2021, Simple and Practical Medical Education, LLC. All rights reserved. May not be reproduced in any form without express written permission.
Disclaimer: The content on this website is provided as general education for medical professionals. It is not intended or recommended for patients or other laypersons or as a substitute for medical advice, diagnosis, or treatment. Patients must always consult a qualified health care professional regarding their diagnosis and treatment. Healthcare professionals should always check this website for the most recently updated information.