Varenicline (US brand name Chantix®) is a nicotinic receptor partial agonist. Here is basic information about this medication.
FDA-approved indications
Used as an aid to smoking cessation treatment
Dosage
Treatment with varenicline can be started one week before patients stops smoking. Alternatively patient can stop smoking on days 8-35 after starting treatment with varenicline.
Week 1: 0.5 mg once daily on days 1-3 and 0.5 mg twice daily on days 4-7.
Weeks 2-12: 1 mg twice daily
Varenicline should be taken with full glass of water.
If the patient is successful in quitting smoking then repeat for 12 weeks.
If the patient is motivated but not successful in quitting smoking, then address the factors responsible for failure of treatment before restarting the treatment.
If the patient cannot tolerate the adverse effects, then consider a temporary or permanent dose reduction.
Special populations
a. Impaired renal function: Mild to moderate impairment requires no dosage adjustment. In severe impairment start with 0.5 mg once daily, then titrate to maximum of 0.5 mg twice daily.
b. Impaired hepatic function: No dosage adjustment is necessary
c. Elderly: Monitor renal function
Dosage forms and strengths
Tablets: 0.5 mg, 1 mg
Please refer to Prescribing Information (see link below) for complete discussion of dosage, administration, warnings and precautions, contraindications, etc.
Related Pages
Substance Use in the DSM-V
Substance Use Disorder: Index and Links
References
Prescribing Information for varenicline (Chantix®)
Copyright 2016, Rajnish Mago, MD. All rights reserved. May not be reproduced in any form without express written permission.
Disclaimer: The content on this website is provided as general education for medical professionals. It is not intended or recommended for patients or other laypersons, or as a substitute for medical advice, diagnosis, or treatment. Patients must always consult a qualified health care professional regarding their diagnosis and treatment. Healthcare professionals should always check this website for the most recently updated information.
Leave a Reply