Sertraline (US brand name Zoloft® and generic) is a selective serotonin reuptake inhibitor (SSRI). Here is key information about this medication.
FDA-approved indications
Major Depressive Disorder
Obsessive-Compulsive Disorder
Panic Disorder
Post-Traumatic Disorder
Social-Anxiety Disorder
Premenstrual Dysphoric Disorder
Dosage
I. Adult patients
Major Depressive Disorder
Initial: 50 mg/day
Maintenance: 50-200 mg/day
Obsessive-Compulsive Disorder
Initial: 50 mg/day
Maintenance: 50-200 mg/day
Panic Disorder
Initial: 25 mg/day, increased to 50 mg/day after one week
Maintenance: 50-200 mg/day
Post-Traumatic Stress Disorder
Initial: 25 mg/day, increased to 50 mg/day after one week
Maintenance: 50-200 mg/day
Social Anxiety Disorder
Initial: 25 mg/day, increased to 50 mg/day after one week
Maintenance: 50-200 mg/day
Premenstrual Dysphoric Disorder
Initial: 50 mg/day (luteal phase or throughout menstrual cycle), increase up to 50 mg/ menstrual cycle to maximum of 100 mg/day (luteal cycle) or 150 mg/day (throughout menstrual cycle)
Maintenance: Reassess for continued treatment at lowest effective dose after 3 weeks of initial treatment
II. Pediatric Patients
Obsessive-Compulsive Disorder
Initial: 25 mg/day (6-12 yrs) or 50 mg/day (13-17 yrs)
Maintenance: 25-200 mg/day (6-17 yrs)
General Instructions: Administered once daily either in the morning or evening
Dosage forms and strengths
Tablets (Zoloft® and generic): 25 mg, 50 mg and 100 mg scored. Generic also available in 150 mg and 200 mg strengths.
Oral concentrate (Zoloft® and generic): 20 mg/mL (administered by mixing with 1/2 cup of water, ginger ale, lemon/lime soda, lemonade or orange juice ONLY)
Please refer to Prescribing Information (see link below) for complete discussion of dosage, administration, warnings and precautions, contraindications, etc.
Related Pages
Three SSRIs that may cause QT prolongation
How and when to titrate up antidepressants
Different and confusing ways in which antidepressants are classified
Antidepressants: Index and Links
Psychopharmacology: Index and Links
References
Prescribing information for sertraline (Zoloft®)
Copyright 2016, Rajnish Mago, MD. All rights reserved. May not be reproduced in any form without express written permission.
Disclaimer: The content on this website is provided as general education for medical professionals. It is not intended or recommended for patients or other laypersons, or as a substitute for medical advice, diagnosis, or treatment. Patients must always consult a qualified health care professional regarding their diagnosis and treatment. Healthcare professionals should always check this website for the most recently updated information.
Leave a Reply