By Rajnish (“Raj”) Mago, MD (bio)
This article was published on May 6, 2022. It was last updated/ edited on May 7, 2022.
Several of the medications being used to treat COVID-19, whether FDA-approved or not, can have significant drug interactions with other medications the patient may be on. It is difficult, if not impossible, to remember and keep track of all these possible drug interactions.
Fortunately, there is a fantastic resource for looking up drug interactions between any of the COVID-19 treatments and other medications:
COVID-19 Drug interactions (University of Liverpool)
The website also has links to other resources, including app versions of the interaction checker.
Interaction checker
Clicking on “Interaction Checker” brings us to the search box. In the first column, we choose the medication for the treatment of COVID-19. In the second column, we choose the other medication(s). The potential drug interaction is shown in the third column.
Here is an example of a search I did—between Paxlovid™ and clozapine.
If we click on the result—the words “Do Not Coadminister” in the red-colored box, an explanation of the drug interaction pops up (see the image below).
Next, please see the following article on this website:
Nirmatrelvir-ritonavir (Paxlovid™): Drug interactions with psychiatric medications
External resources
COVID-19 Drug interactions (University of Liverpool)
Fact Sheet for Healthcare Providers: Emergency Use Authorization for Paxlovid™
National Institutes of Health. Ritonavir-Boosted Nirmatrelvir (Paxlovid)
Related Pages
A simple guide to the COVID-19 vaccines
A primer on tests for identifying 2019 Coronavirus (SARS-CoV-2) infection
Important recommendations regarding sex and coronavirus
What mental health clinicians can do about the coronavirus
Could psychotropic medications affect the immune response to coronavirus?
Helping persons with OCD deal with the coronavirus pandemic
The relationship between COVID-19 and mental disorders (and what we should do about it)
Mental disorders and the immune system
Cytochrome P450 system and psychiatric medications: An introduction and important tips
Cytochrome P450 3A4: Substrates, inhibitors, and inducers
The Flockhart P450 Drug Interaction Table: Full table (Link to external site)
Supplement to Flockhart table
Antidepressants with much fewer P450 drug interactions
One exit door or many?
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