By Rajnish (“Raj”) Mago, MD (bio)
This article was published on May 6, 2022. It was last reviewed on July 4, 2024.
Several of the medications being used to treat COVID-19, whether FDA-approved or not, can have significant drug interactions with other medications the patient may be on. It is difficult, if not impossible, to remember and keep track of all these possible drug interactions.
Fortunately, there is a fantastic resource for looking up drug interactions between any of the COVID-19 treatments and other medications:
COVID-19 Drug interactions (University of Liverpool)
The website also has links to other resources, including app versions of the interaction checker.
Interaction checker
Clicking on “Interaction Checker” brings us to the search box. In the first column, we choose the medication for the treatment of COVID-19. In the second column, we choose the other medication(s). The potential drug interaction is shown in the third column.
Here is an example of a search I did—between Paxlovid™ and clozapine.
If we click on the result—the words “Do Not Coadminister” in the red-colored box, an explanation of the drug interaction pops up (see the image below).
Next, please see the following article on this website:
Nirmatrelvir-ritonavir (Paxlovid™): Drug interactions with psychiatric medications
Related Pages
Drug interactions with COVID-19 medications
COVID-19 drug interaction checker
Nirmatrelvir-ritonavir (Paxlovid™): Drug interactions with psychiatric medications
Can patients on lurasidone take nirmatrelvir + ritonavir (Paxlovid®)?
Drug interaction search (checker) tools
Drug interaction search (checker) tools: Free options
Drug interaction search (checker) tools: Paid options
Levels of seriousness in drug interaction search results
Video: How to do efficient drug interaction searches to quickly identify the important ones
Clinical example: Why we should ALWAYS do a quick drug interaction search
Who’s job is it to check for drug interactions?
COVID-19 drug interaction checker
How to check for drug interactions with an herbal product like ashwagandha
How to easily search for drug interactions with cannabidiol
Cytochrome P450 drug interactions
Cytochrome P450 system and psychiatric medications: An introduction and important tips
Cytochrome P450 3A4: Substrates, inhibitors, and inducers
What the FDA’s “Table of Pharmacogenetic Associations” says about psychotropic medications
Pharmacogenetic testing in the office: Cytochrome P450 enzymes
The Flockhart P450 Drug Interaction Table: Full table (Link to external site)
Supplement to Flockhart table
Antidepressants with much fewer P450 drug interactions
Doxepin and cytochrome P450 drug interactions
One exit door or many?
Cytochrome P450 drug interactions with benzodiazepines
References
COVID-19 Drug interactions (University of Liverpool)
Fact Sheet for Healthcare Providers: Emergency Use Authorization for Paxlovid™
National Institutes of Health. Ritonavir-Boosted Nirmatrelvir (Paxlovid)
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