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Doxepin and cytochrome P450 drug interactions

Question from a Member: Since doxepin is a tricyclic, should we be concerned about adding it at any dose to a patient already on a 2D6 inhibitor of any kind (like an antidepressant) for fear of QTc prolongation? In answering our Member’s question, we need to discuss and understand some wider principles related to drug…

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