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CNSDose®


CNSDose® is a proprietary, commercially-available battery of pharmacogenomic tests (CNSDose, LLC).

The test battery includes evaluation of genetic variations in the genes coding for:

1. Cytochrome P450 isoenzymes CYP2D6 and CYP2C19. Other CYP450 isoenzymes are not evaluated as of February 2017.

2. UGT1A1 (UDP-glucuronosyltransferase 1A1) which is a phase II metabolism enzyme

3. Two ATP-binding cassette (ABC) efflux transporters (ABCB1 and ABCC1) that affect the entry of certain molecules across the blood–brain barrier


Related Pages

Commercially available pharmacogenomic test panels

Genecept assay® (Genomind, Inc)

GeneSight® pharmacogenomic test (Assurex Health)

5-HTTLPR and efficacy of antidepressants

5-HTTLPR and adverse effects of antidepressants 

5-HTTLPR and antidepressant-induced mania 

Pharmacogenomic testing: Main page (links to all pages on this topic)


References

https://www.cnsdose.com/

Bousman CA, Müller DJ, Ng CH, Byron K, Berk M, Singh AB. Concordance between actual and pharmacogenetic predicted desvenlafaxine dose needed to achieve remission in major depressive disorder: a 10-week open-label study. Pharmacogenet Genomics. 2017 Jan;27(1):1-6. PubMed PMID: 27779571; PubMed Central PMCID: PMC5152629.

Singh AB. Improved Antidepressant Remission in Major Depression via a Pharmacokinetic Pathway Polygene Pharmacogenetic Report. Clin Psychopharmacol Neurosci. 2015 Aug 31;13(2):150-6. PubMed PMID: 26243841; PubMed Central PMCID: PMC4540033.

Singh AB, Bousman CA, Ng CH, Byron K, Berk M. ABCB1 polymorphism predicts escitalopram dose needed for remission in major depression. Transl Psychiatry. 2012 Nov 27;2:e198. PubMed PMID: 23188198; PubMed Central PMCID: PMC3565756.


Copyright © 2017, Rajnish Mago, MD. All rights reserved. May not be reproduced in any form without express written permission.

Disclaimer: The content on this website is provided as general education for medical professionals. It is not intended or recommended for patients or other laypersons or as a substitute for medical advice, diagnosis, or treatment. Patients must always consult a qualified health care professional regarding their diagnosis and treatment. Healthcare professionals should always check this website for the most recently updated information.

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