This page was last updated/ edited on February 25, 2023.
Clonidine extended-release (US brand name Kapvay® and generic) is a centrally-acting alpha2-adrenergic agonist.
On this page, we will provide basic information about this medication. Links to other articles on this website with more advanced information and tips related to this medication and related topics are provided below—under Related pages below.
Treatment of attention deficit hyperactivity disorder (ADHD):
– As monotherapy, or
– As adjunctive therapy to stimulant medications
Dosage needs to be individualized according to therapeutic needs and response. Initiated with 0.1 mg at bedtime and then adjusted in 0.1 mg/day increments at weekly intervals until the desired response is achieved. Doses should be taken twice a day, with either an equal or higher split dosage being given at bedtime.
Starting: 0.1 mg/day at bedtime and then adjusted weekly as below until desired response
Morning: 0.1 mg/day, Bedtime: 0.1 mg/day (Total: 0.2 mg/day)
Morning: 0.1 mg/day, Bedtime: 0.2 mg/day (Total: 0.3 mg/day)
Morning: 0.2 mg/day, Bedtime: 0.2 mg/day (Total: 0.4 mg/day)
- Tablets should NOT be crushed, chewed or broken before swallowing.
- Do not substitute for other clonidine products on a mg-per-mg basis, because of differing pharmacokinetic profiles
- Doses higher than 0.4 mg/day have not been evaluated and therefore not recommended.
- Since it has not been systematically evaluated for long-term maintenance treatment, physicians should periodically assess usefulness if prescribed for extended periods.
The total dose should be tapered in decrements of no more than 0.1 mg every 3 to 7 days
Dosage forms and strengths
Extended-release tablets (brand name and generic): 0.1 mg
and 0.2 mg
(0.2 mg tablets are no longer available as either generic or brand name)
The half-life of clonidine is about 12 hours but in some persons, it may extend even up to 24 hours (Almanac et al., 2014).
Important! This page does not provide all the information needed to prescribe this medication. Please refer to the full Prescribing Information (see link below) before prescribing this medication.
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