Buspirone (brand name Buspar® in the US, which has been discontinued) is an anxiolytic with a unique mechanism of action and not related chemically or pharmacologically to benzodiazepines or barbiturates. It is a partial agonist at post-synaptic serotonin 1A receptors and a full agonist at pre-synaptic serotonin 1A receptors. Here is basic information about this medication.
1. Management of Generalized Anxiety Disorder
2. Short-term relief of symptoms of anxiety
Initial: 15 mg daily (7.5 mg twice daily)
Dose may be increased 5 mg per day at intervals of 2 to 3 days
Maximum: 60 mg daily
Patients should take buspirone in a consistent manner with regard to the timing of dosing; either always with or always without food.
Avoid concurrent administration with monoamine oxidase inhbitors (MAOIs) since it may lead to increase in blood pressure.
Avoid in patients with severe hepatic or renal impairment.
Dosage forms and strengths
5 mg (scored)
7.5 mg (scored)
10 mg (scored)
15 mg (multi-scored, bisected or trisected; can be broken into either two or three parts. Can provide either 5 mg, 7.5 mg, or 15 mg)
30 mg (multi-scored, bisected or trisected; can be broken into either two or three parts. Can provide either 10 mg, 15 mg, or 30 mg)
Please refer to Prescribing Information (see below) for complete discussion of dosage, administration, and contraindications.
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