If you would like to re-read the material for a particular question, you can click on the link that is provided along with the correct answer.
1. What effect does smoking cannabis or cigarettes have on serum levels of asenapine, olanzapine, and clozapine?
A. Increased serum levels
B. Decreased serum levels
C. No change in serum levels
Click here to see the answer
Correct answer: B. Decreased serum levels
Explanation: Smoking cannabis or cigarettes regularly leads to induction of the CYP450 1A2 enzyme that metabolizes asenapine, olanzapine, and clozapine (among other medications). So, their serum levels are reduced. This can be very clinically significant, e.g., leadiing to relapse when a patient starts or resumes smoking.
Link: Effects of cannabis or cannabinoids on the cytochrome P450 enzymes
2. This test should be done before starting acamprosate (brand name Campral) for alcohol use disorder.
A. Hepatic function tests
B. Serum creatinine
C. ECG
D. B12 level
Click here to see the answer
Correct answer: B. Serum creatinine
Explanation: Acamprosate is not metabolized and is excreted unchanged by the kidney. So, its levels are greatly affected by impairment in renal function but not by impairment in hepatic function.
Link: Tips on using acamprosate (Campral®) for alcohol use disorder
3. The decrease in GFR (in mL/min/1.73m2) in Stage 1 of chronic kidney disease is:
A. 60- 89
B. 45 – 59
C. 30 – 44
D. No decrease in GFR
Click here to see the answer
Correct answer: D. No decrease in GFR
Explanation: In stage 1 of chronic kidney disease, there is evidence of renal damage (e.g., proteinuria), but the GFR is normal.
Link: Stages of kidney disease
Related Pages
365 Advanced Topics in Psychopharmacology: Quiz 13
365 Advanced Topics in Psychopharmacology: Quiz 14
365 Advanced Topics in Psychopharmacology: Quiz 15
Copyright © 2018, Rajnish Mago, MD. All rights reserved. May not be reproduced in any form without express written permission.
Disclaimer: The content on this website is provided as general education for medical professionals. It is not intended or recommended for patients or other laypersons, or as a substitute for medical advice, diagnosis, or treatment. Patients must always consult a qualified health care professional regarding their diagnosis and treatment. Healthcare professionals should always check this website for the most recently updated information.
Leave a Reply