This article was published on May 13, 2022. The so-called “Z-drugs” is one of the most commonly used classes of hypnotic medications. In the USA, four preparations of “Z-drugs” are available for use as hypnotics—zaleplon (Sonata®), zolpidem (Ambien®), zolpidem controlled-release (Ambien CR®), and eszopiclone (Lunesta®). Often, clinicians have a favorite one and prescribe it to…