Why isn’t bupropion the most frequently prescribed antidepressant?

Question from a Member: Given its side effect profile and efficacy, why isn’t bupropion universally considered first-line for major depression? This is the exact question that Mark Zimmerman (who is on our Editorial Board) asked in a paper he published that had a really cool title: Why isn’t bupropion the most frequently prescribed antidepressant? (Zimmerman et al., 2005). The…