Which causes more weight gain—venlafaxine or duloxetine?

This article was first published on May 17, 2023. It was last reviewed/ updated on May 18, 2023. Question from a Member: I have a patient who is on duloxetine 90 mg/day and feels it is the reason for her weight gain. She wants to switch to venlafaxine, another SNRI [serotonin-norepinephrine reuptake inhibitor]. Will this…