Vortioxetine (Trintellix®): Pharmacological Effects

Vortioxetine has been called a “multi-modal antidepressant.” That is a fancy term, but what does it mean? Firstly, like the SSRIs, vortioxetine inhibits the serotonin transporter. But in addition, it has five effects on post-synaptic receptors as follows: 5-HT1A agonist 5-HT1B partial agonist 5-HT1D antagonist ______________________________________________ 5-HT3A antagonist 5-HT7 antagonist Negative feedback of serotonin releaseSerotonin…