Vortioxetine (Trintellix®): Drug Interactions

What drug interactions can vortioxetine cause? Vortioxetine does not significantly induce or inhibit any CYP450 isoenzyme. However, vortioxetine is 98% protein bound and so it can displace other highly protein bound medications like warfarin, digoxin, etc. What drugs can affect vortioxetine levels? Vortioxetine is mainly metabolized by cytochrome P450 isoenzyme 2D6. For a list of…