Tricyclic/Tetracyclic Antidepressants (TCAs): An overview

Structure of tricyclic/tetracyclic antidepressants 1. For tricyclic antidepressants, it is clinically-relevant to know that they are of two types–tertiary amines and secondary amines. The tertiary amines have more methyl groups. If they lose one methyl group, they are transformed into a secondary amine. As we will see below, the tertiary amines and secondary amines have significantly…