SNRIs differ in the extent of norepinephrine reuptake inhibition

When we move from SSRIs to SNRIs, we do that because we want dual reuptake inhibition, right? But, the SNRIs are not all the same in terms of the extent to which they inhibit serotonin reuptake versus norepinephrine reuptake. They are on a spectrum. The pharmacological effects of antidepressants in the living human brain are complex…