Quetiapine (US brand names Seroquel® and Seroquel XR®) is a second-generation (“atypical”) antipsychotic. Here is basic information about this medication.
Quetiapine (Seroquel® and generic)
FDA-approved indications
Schizophrenia
Bipolar I disorder manic episodes
Bipolar disorder, depressive episodes
Dosage
1. Schizophrenia (adults)
Initial: 25 mg twice daily
Recommended: 150–750 mg/day
Maximum: 750 mg/day
2. Schizophrenia (adolescents, 13-17 yrs)
Initial: 25 mg twice daily
Recommended: 400–800 mg/day
Maximum: 800 mg/day
3. Bipolar mania (monotherapy or as an adjunct to lithium or valproate in adults)
Initial: 50 mg twice daily
Recommended: 400–800 mg/day
Maximum: 800 mg/day
4. Bipolar mania (monotherapy in children and adolescents, 10-17 yrs)
Initial: 25 mg twice daily
Recommended: 400–600 mg/day
Maximum: 600 mg/day
5. Bipolar depression (adults)
Initial: 50 mg once daily at bedtime
Recommended: 300 mg/day
Maximum: 300 mg/day
Dosage forms and strengths
Tablets: 25 mg, 50 mg, 100 mg, 200 mg, 300 mg, 400 mg. Generic is also available in 150 mg strength.
Please refer to Prescribing Information (see link below) for a complete discussion of dosage, administration, warnings and precautions, contraindications, etc.
Quetiapine extended-release (Seroquel XR®)
FDA-approved indications
Schizophrenia
Bipolar I disorder manic or mixed episodes
Bipolar disorder, depressive episodes
Major depressive disorder, adjunctive therapy with antidepressants
Dosage
1. Schizophrenia (adults)
Initial: 300 mg/day
Recommended: 400–800 mg/day
Maximum: 800 mg/day
2. Schizophrenia (adolescents, 13-17 yrs)
Initial: 50 mg/day
Recommended: 400–800 mg/day
Maximum: 800 mg/day
3. Bipolar I disorder, manic or mixed episode (acute monotherapy or as an adjunct to lithium or divalproex in adults)
Initial: 300 mg/day
Recommended: 400–800 mg/day
Maximum: 800 mg/day
4. Bipolar I disorder, manic (acute monotherapy in children and adolescents, 10-17 yrs)
Initial: 50 mg/day
Recommended: 400–600 mg/day
Maximum: 600 mg/day
5. Bipolar disorder, depressive episodes (adults)
Initial: 50 mg/day
Recommended: 300 mg/day
Maximum: 300 mg/day
6. Major depressive disorder, adjunctive therapy with antidepressants (adults)
Initial: 50 mg/day
Recommended: 150–300 mg/day
Maximum: 300 mg/day
Instruct patients to swallow whole and not to split, chew, or crush the tablets. Patients may take the tablets without food or with a light meal once daily, preferably in the evening.
Elderly or patients with hepatic impairment should be considered for a lower starting dose (50 mg/day)
Dosage forms and strengths
Extended-release tablets: 50 mg, 150 mg, 200 mg, 300mg, and 400 mg
Please refer to Prescribing Information (see link below) for a complete discussion of dosage, administration, warnings and precautions, contraindications, etc.
Related Pages
Second-Generation Antipsychotics: Dose Equivalents
Antipsychotics and QT prolongation
Antibiotics, Antipsychotics, and QTc Prolongation
What should I be doing to monitor patients who are on an antipsychotic? (Free)
Second-generation (“Atypical”) antipsychoticsA
References
Quetiapine (Seroquel®) Prescribing Information
Quetiapine extended-release (Seroquel XR®) Prescribing Information
Copyright 2016, Rajnish Mago, MD. All rights reserved. May not be reproduced in any form without express written permission.
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