Warning! Prazosin can lead to hypotension/ syncope after the first dose

In the US, prazosin carries a bolded warning that, as with all alpha-blockers, it can cause syncope with sudden loss of consciousness. This syncope usually occurs after the very first dose ever taken by that person– the so-called “first-dose phenomenon.” Other symptoms that can also occur after the first dose include palpitations, feelings of unreality,…