Long-acting injectable (LAI) antipsychotics: Overview

Long-acting injectable (LAI) or “depot” antipsychotics are important because of the widespread problem of nonadherence to medication.

The second-generation (“atypical”) antipsychotics available in the USA as long-acting injectables are, alphabetically:

1. Aripiprazole monohydrate (Abilify Maintena®)

2. Aripiprazole lauroxil (Aristada®)

3. Aripiprazole lauroxil (Aristada Initio®)—Only for starting or restarting aripiprazole lauroxil (Aristada®)

4. Olanzapine pamoate (Zyprexa Relprevv®)

5. Paliperidone palmitate (Invega Sustenna®)

6. Paliperidone palmitate 3-monthly (Invega Trinza®)

7. Paliperidone palmitate 6-monthly (Invega Hafyera®)

8. Risperidone long-acting injection (Risperdal Consta®)

9. Risperidone long-acting injectable for subcutaneous use (Perseris®)

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Related Pages

Dose equivalents of long-acting injectable second-generation antipsychotics

CPT billing code for administration of injections

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Aripiprazole (Abilify Maintena®)

Aripiprazole lauroxil (Aristada®)

Aripiprazole lauroxil (Aristada®) versus Aripiprazole (Abilify Maintena®)

Aripiprazole lauroxil (Aristada Initio®)

Be careful in converting from Abilify Maintena® to Aristada®

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Olanzapine (Zyprexa Relprevv®)

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Paliperidone palmitate (Invega Sustenna®)

Paliperidone palmitate 3-month (Invega Trinza®)

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Risperidone long-acting injection (Risperdal Consta®): Basic Information

Equivalence of risperidone oral and long-acting injection (RLAI; Risperdal Consta®)

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References

Miyamoto S, Wolfgang Fleischhacker W. The Use of Long-Acting Injectable Antipsychotics in Schizophrenia. Curr Treat Options Psychiatry. 2017;4(2):117-126. Review. PubMed PMID: 28580230; PubMed Central PMCID: PMC5432557.

Khan AY, Salaria S, Ovais M, Ide GD. Depot antipsychotics: Where do we stand? Ann Clin Psychiatry. 2016 Nov;28(4):289-298. PubMed PMID: 27901520.

Citrome L. Aripiprazole long-acting injectable formulations for schizophrenia: aripiprazole monohydrate and aripiprazole lauroxil. Expert Rev Clin Pharmacol. 2016;9(2):169-86. Review. PubMed PMID: 26573020.

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