Long-acting injectable antipsychotics: Overview

Long-acting injectable (or “depot”) antipsychotics are important because of the widespread problem of nonadherence to medication. The second-generation (“atypical”) antipsychotics available in the USA are, alphabetically:

1. Aripiprazole (Abilify Maintena®)

2. Aripiprazole lauroxil (Aristada®)

3. Olanzapine (Zyprexa Relprevv®)

4. Paliperidone palmitate (Invega Sustenna®)

5. Paliperidone palmitate 3-month (Invega Trinza®)

6. Risperidone long-acting injection (Risperdal Consta®)

 References

Miyamoto S, Wolfgang Fleischhacker W. The Use of Long-Acting Injectable Antipsychotics in Schizophrenia. Curr Treat Options Psychiatry. 2017;4(2):117-126. Review. PubMed PMID: 28580230; PubMed Central PMCID: PMC5432557.

Khan AY, Salaria S, Ovais M, Ide GD. Depot antipsychotics: Where do we stand? Ann Clin Psychiatry. 2016 Nov;28(4):289-298. PubMed PMID: 27901520.

Citrome L. Aripiprazole long-acting injectable formulations for schizophrenia: aripiprazole monohydrate and aripiprazole lauroxil. Expert Rev Clin Pharmacol. 2016;9(2):169-86. Review. PubMed PMID: 26573020.

Copyright 2017, Rajnish Mago, MD. All rights reserved. May not be reproduced in any form without express written permission.

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