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Long-acting injectable (LAI) antipsychotics: Overview

Long-acting injectable (LAI) or “depot” antipsychotics are important because of the widespread problem of nonadherence to medication.

The second-generation (“atypical”) antipsychotics available in the USA as long-acting injectables are, alphabetically, listed below:


LAI preparations of aripiprazole

  1. Aripiprazole monohydrate (Abilify Maintena®)

  2. Aripiprazole extended-release injectable suspension (Abilify Asimtufii®)

  3. Aripiprazole lauroxil (Aristada®)

  4. Aripiprazole lauroxil (Aristada Initio®)—Only for starting or restarting aripiprazole lauroxil (Aristada®)

Also see the following related articles on this website:

Aripiprazole lauroxil (Aristada®) versus Aripiprazole (Abilify Maintena®)

How to convert from oral to long-acting injectable (LAI) aripiprazole

Be careful in converting from Abilify Maintena® to Aristada®

Why does Abilify Maintena® have an FDA indication for bipolar disorder but Aristada® does not?


LAI preparations of olanzapine

  1. Olanzapine pamoate (Zyprexa Relprevv®)

Also see the following related article on this website:

Extended-Release Olanzapine (Zyprexa Relprevv®): REMS


LAI preparations of paliperidone

  1. Paliperidone palmitate (Invega Sustenna®)

  2. Paliperidone palmitate 3-monthly (Invega Trinza®)

  3. Paliperidone palmitate 6-month (Invega Hayfera®)


LAI preparations of risperidone

  1. Risperidone extended-release injectable suspension (Uzedy®)

  2. Risperidone long-acting injection (Risperdal Consta®)

  3. Risperidone long-acting injectable for subcutaneous use (Perseris®)

  4. Risperidone for extended-release injectable suspension, for intramuscular use (Rykindo®)

Also see the following related article on this website:

Equivalence of risperidone oral and long-acting injection (RLAI; Risperdal Consta®)


Related Pages

LAI second-generation antipsychotics—General articles

Long-acting injectable antipsychotics: Overview

Dose equivalents of long-acting injectable second-generation antipsychotics

How *NOT* to offer long-acting injectable (LAI) antipsychotics to patients

Which injections can only be given in the gluteal muscle—and why?

How to choose between injecting into the deltoid or gluteal muscles

CPT billing code for administration of injections

When is it appropriate to combine two antipsychotics?


References

Miyamoto S, Wolfgang Fleischhacker W. The Use of Long-Acting Injectable Antipsychotics in Schizophrenia. Curr Treat Options Psychiatry. 2017;4(2):117-126. Review. PubMed PMID: 28580230; PubMed Central PMCID: PMC5432557.

Khan AY, Salaria S, Ovais M, Ide GD. Depot antipsychotics: Where do we stand? Ann Clin Psychiatry. 2016 Nov;28(4):289-298. PubMed PMID: 27901520.

Citrome L. Aripiprazole long-acting injectable formulations for schizophrenia: aripiprazole monohydrate and aripiprazole lauroxil. Expert Rev Clin Pharmacol. 2016;9(2):169-86. Review. PubMed PMID: 26573020.

Krishna A, Goicochea S, Shah R, Stamper B, Harrell G, Turner A. A Comprehensive Guide to Long-Acting Injectable Antipsychotics for Primary Care Clinicians. J Am Board Fam Med. 2024 Jul-Aug;37(4):773-783. doi: 10.3122/jabfm.2022.220425R2. PMID: 39455270.

Markowicz-Piasecka M, Kubisiak M, Asendrych-Wicik K, Kołodziejczyk M, Grzelińska J, Fabijańska M, Pietrzak T. Long-Acting Injectable Antipsychotics-A Review on Formulation and In Vitro Dissolution. Pharmaceutics. 2023 Dec 24;16(1):28. doi: 10.3390/pharmaceutics16010028. PMID: 38258037; PMCID: PMC10820045.

VandenBerg AM. An update on recently approved long-acting injectable second-generation antipsychotics: Knowns and unknowns regarding their use. Ment Health Clin. 2022 Nov 3;12(5):270-281. doi: 10.9740/mhc.2022.10.270. PMID: 36405505; PMCID: PMC9645288.


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Disclaimer: The material on this website is provided as general education for medical professionals. It is not intended for patients or other laypersons, nor is it a substitute for medical advice, diagnosis, or treatment. Patients must always consult a qualified healthcare professional regarding their diagnosis and treatment. Healthcare professionals should always check this website for the most up-to-date information.

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