How much better is olanzapine-samidorphan (Lybalvi®) than olanzapine alone?

This article was first published on March 27, 2023. It was last reviewed/ updated on March 30, 2023. The combination of olanzapine and samidorphan (an opioid antagonist) is available in the United States under the brand name Lybalvi®. Combining samidorphan with olanzapine has been shown to reduce weight gain compared to treatment with olanzapine alone….