Which tricyclic antidepressants (TCAs) are the most effective ones for major depressive disorder (MDD)?

By Rajnish Mago, MD (bio) Comment from a Member who is well known as an expert on “treatment-resistant depression”: “In my opinion, it is better to use a dual-reuptake TCA than a noradrenergic alone one such as nortriptyline. Better options may be clomipramine, imipramine, and amitriptyline. Such agents have a broader spectrum, pharmacodynamically.” My response…