Question: Is mirtazapine (Remeron) better than SSRIsĀ for the treatment of major depressive disorder? Second question: Which adverse effects are more likely to occur with mirtazapine (Remeron)? Other than excessive sleepiness and weight gain; we already know about those two. One meta-analysis (Papakostas et al., 2008) combined data from ten randomized, controlled trials (total n= 1904)…