Methotrexate may be the cause of many psychiatric symptoms

This article was published on June 15, 2022. Clinical case One of my outpatients suffers from recurrent major depressive disorder but has been symptom-free on a combination of escitalopram 20 mg/day and bupropion extended-release 450 mg/day. She also has rheumatoid arthritis and receives a course of methotrexate every few years when she has a flare-up….