What to do about methadone-related QTc prolongation

Methadone has been associated with clinically-significant prolongation of the QTc interval (Perrin-Terrin et al., 2011; Pearson and Woosley, 2005). How serious can this methadone-induced QTc prolongation be? Many cases of torsades de pointes attributed to methadone have been reported (Pearson and Woosley, 2005). And, a few of these patients died (Perrin-Terrin et al., 2011; Pearson…