Extending the action of melatonin: extended/time/sustained-release or bi-layer/dual spectrum

This article was first published on April 30, 2024. It was last reviewed, updated, or edited on April 30, 2024. Melatonin has a short half-life—an average of only about 45 minutes (Andersen et al., 2016). But a longer duration of action of melatonin is desirable for the treatment of both insomnia and REM sleep behavior…