Extending the action of melatonin: extended/time/sustained-release or bi-layer/dual spectrum

Melatonin has a short half-life—an average of only about 45 minutes (Andersen et al., 2016). But a longer duration of action of melatonin is desirable for the treatment of both insomnia and REM sleep behavior disorder. So, many different formulations of melatonin have been developed  (Moroni et al., 2021). Let’s familiarize ourselves with some of…