What should we do about valproate-induced macrocytosis?

This article was first published on October 21, 2024. Question from a Member: When a patient develops macrocytosis secondary to divalproex (Depakote®) use, at what point should discontinuation of divalproex be considered? For a brief introduction to macrocytosis, please see the following article on this website: Macrocytosis: A brief summary for mental health clinicians Hematological…