Lurasidone (Latuda®): Drug Interactions

How is lurasidone metabolized and what drug interactions can that lead to? Lurasidone is metabolized only by cytochrome P450 3A4. Potent inducers and inhibitors of CYP3A4 can, respectively, significantly decrease or increase levels of lurasidone. What about binding to plasma proteins? Lurasidone is highly bound (99%) to plasma proteins. Therefore, it can displace other drugs…