Long-acting injectable (LAI) antipsychotics: Overview

This article was last reviewed, updated, or edited on May 11, 2024.

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Long-acting injectable (LAI) or “depot” antipsychotics are important because of the widespread problem of nonadherence to medication.

The second-generation (“atypical”) antipsychotics available in the USA as long-acting injectables are, alphabetically, listed below:

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1. Aripiprazole monohydrate (Abilify Maintena^®)

2. Aripiprazole (monohydrate)  (Abilify Asimtufii^®)

3. Aripiprazole lauroxil (Aristada^®)

4. Aripiprazole lauroxil (Aristada Initio^®)—Only for starting or restarting aripiprazole lauroxil (Aristada^®)

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1. Olanzapine pamoate (Zyprexa Relprevv^®)

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1. Paliperidone palmitate (Invega Sustenna^®)

2. Paliperidone palmitate 3-monthly (Invega Trinza^®)

3. Paliperidone palmitate 6-monthly (Invega Hafyera^®)

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1. Risperidone extended-release injectable suspension (Uzedy^™)

2. Risperidone long-acting injection (Risperdal Consta^®)

3. Risperidone long-acting injectable for subcutaneous use (Perseris^®)

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Related Pages

Dose equivalents of long-acting injectable second-generation antipsychotics

CPT billing code for administration of injections

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Aripiprazole (Abilify Maintena^®)

Aripiprazole lauroxil (Aristada^®)

Aripiprazole lauroxil (Aristada®) versus Aripiprazole (Abilify Maintena^®)

Aripiprazole lauroxil (Aristada Initio^®)

Be careful in converting from Abilify Maintena® to Aristada^®)

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Olanzapine (Zyprexa Relprevv^®)

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Paliperidone palmitate (Invega Sustenna^®)

Paliperidone palmitate 3-month (Invega Trinza^®)

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Risperidone long-acting injection (Risperdal Consta^®): Basic Information

Equivalence of risperidone oral and long-acting injection (RLAI; Risperdal Consta^®)

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References

Miyamoto S, Wolfgang Fleischhacker W. The Use of Long-Acting Injectable Antipsychotics in Schizophrenia. Curr Treat Options Psychiatry. 2017;4(2):117-126. Review. PubMed PMID: 28580230; PubMed Central PMCID: PMC5432557.

Khan AY, Salaria S, Ovais M, Ide GD. Depot antipsychotics: Where do we stand? Ann Clin Psychiatry. 2016 Nov;28(4):289-298. PubMed PMID: 27901520.

Citrome L. Aripiprazole long-acting injectable formulations for schizophrenia: aripiprazole monohydrate and aripiprazole lauroxil. Expert Rev Clin Pharmacol. 2016;9(2):169-86. Review. PubMed PMID: 26573020.

Markowicz-Piasecka M, Kubisiak M, Asendrych-Wicik K, Kołodziejczyk M, Grzelińska J, Fabijańska M, Pietrzak T. Long-Acting Injectable Antipsychotics-A Review on Formulation and In Vitro Dissolution. Pharmaceutics. 2023 Dec 24;16(1):28. doi: 10.3390/pharmaceutics16010028. PMID: 38258037; PMCID: PMC10820045.

VandenBerg AM. An update on recently approved long-acting injectable second-generation antipsychotics: Knowns and unknowns regarding their use. Ment Health Clin. 2022 Nov 3;12(5):270-281. doi: 10.9740/mhc.2022.10.270. PMID: 36405505; PMCID: PMC9645288.

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