Is lamotrigine a problem in patients on cancer chemotherapy that includes leucovorin?

This article was first published on March 3, 2024. It was last reviewed, updated, or edited on March 3, 2024. One of my outpatients with bipolar II disorder has done extremely well on a combination of medications that includes lamotrigine. Unfortunately, she was diagnosed with a gastrointestinal malignancy. After surgery, she was started on a…