Can isotretinoin (Accutane®, Roaccutane®) cause depression or suicidality?

Clinical situation: The dermatologist for one of my patients who has bipolar disorder which is currently well-controlled called me regarding wanting to start our mutual patient on isotretinoin for the treatment of his severe acne that had not responded to either topical treatment or a long course of doxycycline. The doctor said to me that…