Is mirtazapine less sedating at higher doses?

It has been hypothesized that mirtazapine may be less sedating at doses of 30 mg/day or more compared to doses of 15 mg or less. This belief has become widespread–among patients, prescribing clinicians, and authors of review articles and textbooks. But, is this just a myth that keeps getting propagated? Let’s answer that here. Proposed…