This article was last reviewed/ updated on January 17, 2023.
Iloperidone (US brand name Fanapt®) is a second-generation (“atypical”) antipsychotic. Here is basic information about this medication.
FDA-approved indications
Treatment of adults with schizophrenia.
The FDA indication statement also includes the following (emphasis added):
” In choosing among treatments, prescribers should consider the ability of FANAPT to prolong the QT interval and the use of other drugs first. Prescribers should also consider the need to titrate FANAPT slowly to avoid orthostatic hypotension, which may lead to delayed effectiveness compared to some other drugs that do not require similar titration.”
Dosage
Starting dose: 1 mg twice daily
Titration: The dose should then be increased to 2 mg, 4 mg, 6 mg, 8 mg, 10 mg, and 12 mg twice daily on days 2, 3, 4, 5, 6, and 7 respectively.
Target dose: 6 to 12 mg twice daily (achieved by dose increments of 1–2 mg twice daily)
Maximum dose: The recommended target dosage of iloperidone is 12 to 24 mg/day administered in two divided doses.
Please refer to Prescribing Information (see link below) for a complete discussion of dosage, administration, warnings and precautions, contraindications, etc.
Dosage forms and strengths
Tablets: 1 mg, 2 mg, 4 mg, 6 mg, 8 mg, 10 mg, and 12 mg
Related Pages
Second-generation (“atypical”) antipsychotics (List)
Second-generation antipsychotics: Dose equivalents
Antipsychotics and QT prolongation
Antibiotics, Antipsychotics, and QTc Prolongation
The patient who “demands” TWO antipsychotics
What should I be doing to monitor patients who are on an antipsychotic?
Main menu: Treatments
References
Iloperidone Prescribing Information
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Are there any articles on here comparing the different second generation antipsychotics?
Dr. Deeves:
All our articles about antipsychotics can be seen on the Main menu: Treatments at https://simpleandpractical.com/treatments/
In particular, please see the following articles:
Which second-generation antipsychotics have a lower or higher risk of causing akathisia?
Is TD less likely with second-generation (“atypical”) antipsychotics?
Does any atypical antipsychotic have a lower risk of tardive dyskinesia?
Is lumateperone less likely to cause extrapyramidal symptoms (including parkinsonism or akathisia)?